Zerotil Plus Tablet 500 mg + 125 mg is a broad-spectrum combination antibiotic containing Cefuroxime Axetil and Clavulanic Acid. This formulation is designed to treat moderate to severe bacterial infections, including those caused by beta-lactamase producing resistant organisms. Clavulanic Acid enhances the activity of Cefuroxime by inhibiting bacterial enzymes that destroy antibiotics, making the treatment more effective in resistant infections.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Zerotil Plus Tablet is indicated for the treatment of:

• Lower and upper respiratory tract infections (bronchitis, pneumonia, tonsillitis, sinusitis)
• Ear, nose, and throat (ENT) infections such as otitis media
• Complicated urinary tract infections (UTIs)
• Skin and soft tissue infections
• Mixed or resistant bacterial infections
• Other bacterial infections as prescribed by a physician

Mechanism of Action

This combination works through a dual mechanism:

• Cefuroxime Axetil: A cephalosporin antibiotic that inhibits bacterial cell wall synthesis, leading to bacterial cell death
• Clavulanic Acid: A beta-lactamase inhibitor that protects Cefuroxime from enzymatic degradation by resistant bacteria

Together, they provide enhanced antibacterial activity against a wide range of susceptible and resistant organisms.

Dosage and Administration

• Dosage is determined by a physician based on infection type and severity
• Commonly taken twice daily
• Best taken after meals to improve absorption and reduce gastric discomfort
• Swallow tablet whole with water; do not crush or chew
• Complete the full course even if symptoms improve early to prevent resistance

Benefits

• Broad-spectrum antibacterial coverage
• Effective against resistant bacterial strains
• Enhanced efficacy due to beta-lactamase inhibition
• Useful in respiratory, urinary, and skin infections
• Helps reduce infection-related complications

Side Effects

Common side effects may include:

• Nausea or vomiting
• Diarrhea
• Abdominal pain
• Headache
• Skin rash

Serious side effects (rare):

• Severe allergic reactions (anaphylaxis, swelling, breathing difficulty)
• Clostridium difficile-associated diarrhea
• Liver enzyme abnormalities
• Blood disorders (rare)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision
• Not effective against viral infections
• Use cautiously in patients with penicillin or cephalosporin allergy
• Dose adjustment may be required in renal impairment
• Complete full course to prevent antibiotic resistance
• Inform physician about all current medications

Storage

• Store below 25°C
• Protect from moisture and light
• Keep out of reach of children.