Ziditam Injection is a combination antibiotic therapy containing Ceftazidime 2 gm and Avibactam 0.5 gm per vial. It is a broad-spectrum injectable antibiotic used for the treatment of serious Gram-negative bacterial infections, including infections caused by multi-drug resistant organisms. The combination of a third-generation cephalosporin (Ceftazidime) with a non-β-lactam β-lactamase inhibitor (Avibactam) enhances its activity against β-lactamase producing bacteria, including Enterobacteriaceae and Pseudomonas aeruginosa.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Injectable Antibiotic

• Third-Generation Cephalosporin + β-Lactamase Inhibitor

Pharmacology

Ceftazidime is a β-lactam antibiotic that works by inhibiting bacterial cell wall synthesis. It binds to penicillin-binding proteins (PBPs), interfering with the final transpeptidation step of peptidoglycan synthesis, which results in bacterial cell lysis and death.

Avibactam is a non-β-lactam β-lactamase inhibitor that protects Ceftazidime from enzymatic degradation by class A, C, and some class D β-lactamases. Avibactam restores and extends the activity of Ceftazidime against resistant Gram-negative bacteria, including those producing extended-spectrum β-lactamases (ESBLs) and KPC enzymes.

Together, the combination offers enhanced efficacy against complicated infections where standard cephalosporins may fail.

Indications

Ziditam Injection is indicated for the treatment of:

• Complicated urinary tract infections (cUTIs), including pyelonephritis

• Complicated intra-abdominal infections (cIAIs), in combination with appropriate agents for anaerobic coverage

• Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP)

• Other serious infections caused by susceptible Gram-negative bacteria, particularly multidrug-resistant strains

Dosage & Administration

• Administered intravenously (IV) over 2 hours after reconstitution and dilution

• Adults: Typical dose is 2.5 gm (2 gm Ceftazidime + 0.5 gm Avibactam) every 8 hours, adjusted based on renal function

• Renal Impairment: Dose adjustment is necessary in patients with creatinine clearance <50 mL/min

• Treatment duration varies depending on infection type, severity, and clinical response, generally 5–14 days

Contraindications

• Known hypersensitivity to Ceftazidime, Avibactam, or other β-lactam antibiotics

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Common side effects may include:

• Nausea, vomiting, diarrhea

• Headache

• Local reactions at the injection site (pain, inflammation)

• Rash or pruritus

Serious but rare adverse effects:

• Hypersensitivity reactions including anaphylaxis

• Clostridium difficile-associated diarrhea

• Neutropenia or thrombocytopenia in prolonged use

Precautions & Warnings

• Monitor renal and hepatic function during prolonged therapy

• Use with caution in patients with a history of allergic reactions to β-lactam antibiotics

• Discontinue therapy if severe hypersensitivity or Clostridium difficile infection occurs

• Not recommended for viral infections or non-bacterial illnesses

Pregnancy & Lactation

• Pregnancy: Use only if clearly needed and benefits outweigh risks

• Lactation: Excreted in breast milk in small amounts; consult a physician before use

Storage

• Store below 30°C, protected from light and moisture

• Reconstituted solution should be used immediately or stored as recommended by the manufacturer

• Keep out of reach of children.