A-Fenac Tablet 50 mg contains Diclofenac Sodium, a widely prescribed nonsteroidal anti-inflammatory drug (NSAID) with potent analgesic, anti-inflammatory, and antipyretic properties. It is used for the effective relief of moderate pain and inflammation associated with a variety of acute and chronic musculoskeletal and inflammatory conditions. The 50 mg strength is suitable for patients who require stronger and sustained pain control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

A-Fenac Tablet 50 mg is indicated for the management of pain and inflammation in conditions such as:

• Rheumatoid arthritis

• Osteoarthritis

• Ankylosing spondylitis

• Acute musculoskeletal pain

• Low back pain

• Dental pain and post-extraction pain

• Post-operative and post-traumatic pain

• Dysmenorrhea

• Soft tissue injuries including sprains and strains

By reducing pain and swelling, A-Fenac Tablet helps improve joint mobility and overall functional capacity.

Therapeutic Class

Nonsteroidal anti-inflammatory drugs (NSAIDs)

Pharmacology

Diclofenac Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, leading to decreased synthesis of prostaglandins, which are key mediators of inflammation, pain, and fever. Diclofenac has a strong anti-inflammatory effect along with effective pain relief.

After oral administration, diclofenac is rapidly absorbed from the gastrointestinal tract. It undergoes hepatic metabolism and is highly bound to plasma proteins. The drug is widely distributed to inflamed tissues and synovial fluid, where it exerts its therapeutic action. Excretion occurs mainly via the kidneys and partly through bile.

Mode of Action

A-Fenac Tablet 50 mg reduces inflammation, pain, and fever by blocking prostaglandin production at the site of inflammation. This results in reduced swelling, stiffness, and tenderness, enabling better movement and faster recovery.

Dosage and Administration

Dosage should be tailored to the patient’s condition and response:

• Adults: 50 mg taken two to three times daily

• Elderly patients: Lowest effective dose is recommended

The tablet should be taken after meals to minimize gastrointestinal irritation. Long-term use should be under medical supervision.

Drug Interactions

Diclofenac may interact with anticoagulants, antiplatelet agents, corticosteroids, other NSAIDs, antihypertensive drugs, lithium, methotrexate, and diuretics. These interactions may increase the risk of gastrointestinal bleeding, renal impairment, or altered drug levels.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

A-Fenac Tablet 50 mg is contraindicated in patients with:

• Hypersensitivity to diclofenac or other NSAIDs

• Active peptic ulcer or gastrointestinal bleeding

• Severe hepatic, renal, or cardiac dysfunction

• History of NSAID-induced asthma or allergic reactions

Side Effects

Possible side effects include:

• Gastrointestinal pain, nausea, indigestion, or diarrhea

• Headache or dizziness

• Elevated liver enzymes with prolonged use

• Rarely, gastrointestinal ulceration or bleeding

Most adverse effects are dose- and duration-related.

Pregnancy and Lactation

A-Fenac Tablet should be used with caution during pregnancy and is contraindicated in the third trimester. Use during lactation should be based on medical advice.

Storage Conditions

Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.