Abezino Tablet 200 mg contains Abemaciclib, an oral anticancer medicine used mainly for the treatment of certain types of Breast Cancer, especially hormone-receptor-positive and HER2-negative advanced or metastatic breast cancer. It belongs to a group of targeted anticancer drugs known as cyclin-dependent kinase (CDK) 4 and 6 inhibitors, which help slow or stop the growth of cancer cells.

This medicine is usually prescribed by oncologists either alone or in combination with hormone therapy such as aromatase inhibitors or fulvestrant, depending on the stage of the disease and the patient’s previous treatment history.

Composition

Each film-coated tablet contains:

• Abemaciclib 200 mg

It is formulated for oral administration and should be taken only under the supervision of a qualified healthcare professional.

Therapeutic Class

• Antineoplastic (anticancer) agent

• CDK4/6 inhibitor

• Targeted cancer therapy

Indications

Abezino Tablet 200 mg is primarily indicated for the treatment of:

1. Hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer.

2. Breast cancer that has progressed after endocrine therapy.

3. Early breast cancer with high risk of recurrence when used with endocrine therapy.

4. Combination therapy with drugs such as aromatase inhibitors or fulvestrant for advanced disease.

Doctors may prescribe this medicine either as monotherapy or combined with other hormonal treatments to improve treatment outcomes.

Mechanism of Action

Abemaciclib works by inhibiting cyclin-dependent kinases 4 and 6 (CDK4/6), which are enzymes responsible for controlling cell division. These kinases normally help cancer cells progress through the cell cycle from the G1 phase to the S phase, allowing them to multiply rapidly.

By blocking CDK4/6 activity, abemaciclib prevents phosphorylation of the retinoblastoma protein and stops cancer cells from dividing and growing. As a result, tumor growth slows and cancer cells may eventually die.

Dosage and Administration

• The tablet is taken orally with or without food.

• It should be swallowed whole with water and not crushed or chewed.

• The typical dose for monotherapy is 200 mg twice daily, while combination therapy often uses 150 mg twice daily.

• Treatment usually continues until disease progression or unacceptable toxicity occurs.

Dosage adjustments may be required depending on side effects or liver function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Like many cancer medicines, Abezino Tablet may cause some side effects. Common ones include:

• Diarrhea

• Nausea and vomiting

• Fatigue

• Decreased appetite

• Abdominal pain

• Hair thinning

• Low white blood cell count (neutropenia)

• Anemia

• Increased liver enzymes

Patients should contact their doctor immediately if severe diarrhea, infection symptoms, or unusual bleeding occur.

Precautions and Warnings

Before using Abezino Tablet, the following precautions should be considered:

• Not recommended during pregnancy or breastfeeding.

• Regular blood tests may be required to monitor blood cell counts and liver function.

• Use cautiously in patients with liver impairment.

• Avoid strong CYP3A inhibitors or inducers, which can affect the drug level in the body.

Patients should always inform their doctor about other medications they are taking.

Storage

• Store below 25°C in a cool and dry place.

• Protect from moisture and light.

• Keep out of reach of children.