Alkriz Capsule 250 mg contains Crizotinib, a targeted anticancer medication used in the treatment of certain types of non-small cell lung cancer (NSCLC). It belongs to a class of drugs known as tyrosine kinase inhibitors (TKIs). Crizotinib works by blocking specific abnormal proteins, including ALK (anaplastic lymphoma kinase) and ROS1, which are responsible for the growth and spread of cancer cells.

By targeting these genetic mutations, Alkriz helps slow tumor progression and improve treatment outcomes in eligible patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Alkriz Capsule 250 mg is indicated for:

• ALK-positive metastatic non-small cell lung cancer (NSCLC)
• ROS1-positive metastatic NSCLC
• Locally advanced or metastatic lung cancer with specific genetic mutations
• Treatment of patients identified through approved diagnostic testing

Mechanism of Action

Crizotinib selectively inhibits receptor tyrosine kinases such as ALK, ROS1, and MET. These proteins play a key role in cancer cell signaling, growth, and survival. By blocking these pathways, Alkriz disrupts tumor cell proliferation and induces apoptosis (programmed cell death), thereby controlling disease progression.

Dosage and Administration

• The usual dose is determined by a qualified oncologist based on patient condition
• Typically taken orally twice daily
• Can be taken with or without food
• Capsules should be swallowed whole with water
• Dose adjustments may be required based on tolerance and side effects
• Treatment should be continued only under strict medical supervision

Side Effects

Common side effects may include:

• Nausea and vomiting
• Diarrhea or constipation
• Fatigue
• Vision disturbances (blurred vision, flashes of light)
• Edema (swelling)
• Loss of appetite

Serious side effects may include:

• Liver toxicity
• Interstitial lung disease (lung inflammation)
• QT interval prolongation (heart rhythm changes)
• Severe gastrointestinal symptoms

Immediate medical attention is required if serious reactions occur.

Precautions and Warnings

• Patients must be tested for ALK or ROS1 gene rearrangements before starting therapy
• Regular liver function tests are required
• Monitor for vision changes and cardiac abnormalities
• Use cautiously in patients with liver, kidney, or heart disease
• Not recommended during pregnancy or breastfeeding
• Effective contraception should be used during treatment and after completion

Drug Interactions

Alkriz Capsule may interact with:

• CYP3A inhibitors or inducers
• Antiarrhythmic drugs
• Other anticancer therapies
• Certain antibiotics and antifungals

Always inform your healthcare provider about all medicines being used.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children

Conclusion

Alkriz Capsule 250 mg (Crizotinib) is a targeted therapy used for ALK-positive and ROS1-positive non-small cell lung cancer. When used under proper oncologist supervision, it helps slow cancer progression and improves patient outcomes through precision-based treatment.