Amdova Tablet 5 mg + 10 mg is a fixed-dose combination of Amlodipine Besilate, a long-acting calcium channel blocker, and Atorvastatin, a lipid-lowering agent belonging to the statin class. This combination therapy is designed for patients who require both hypertension management and cholesterol control to reduce the risk of cardiovascular events. By addressing two major cardiovascular risk factors—high blood pressure and elevated LDL cholesterol—Amdova helps improve overall heart health and prevents complications such as heart attack, stroke, and atherosclerosis.

Amlodipine works by relaxing the vascular smooth muscles, leading to vasodilation and reduced peripheral resistance, while Atorvastatin inhibits HMG-CoA reductase, reducing cholesterol synthesis in the liver. Together, they provide a synergistic effect in controlling blood pressure and lipid levels, enhancing cardiovascular protection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Amdova Tablet 5 mg + 10 mg is indicated for:

• Hypertension: Alone or in combination with other antihypertensive therapies

• Hyperlipidemia: To lower elevated total cholesterol, LDL cholesterol, triglycerides, and to increase HDL cholesterol

• Cardiovascular risk reduction: For patients with multiple risk factors including high blood pressure and dyslipidemia

Therapeutic Class

• Calcium Channel Blocker + HMG-CoA Reductase Inhibitor (Statin) Combination

Pharmacology

Amlodipine Besilate

• Inhibits calcium influx into vascular smooth muscle and cardiac muscle

• Causes arterial vasodilation, reducing peripheral resistance and lowering blood pressure

• Reduces myocardial oxygen demand, providing anti-anginal effects

Atorvastatin

• Selectively inhibits HMG-CoA reductase, a key enzyme in cholesterol synthesis

• Reduces LDL cholesterol and triglycerides, while modestly increasing HDL cholesterol

• Stabilizes atherosclerotic plaques, improving vascular health and reducing cardiovascular risk

Combined Action

• Dual therapy targets both blood pressure and lipid levels, two major contributors to cardiovascular morbidity

• Enhances compliance by combining two agents in a single tablet

• Reduces risk of coronary heart disease, stroke, and other atherosclerotic complications

Dosage and Administration

• Adults: Usually 1 tablet once daily, or as directed by a physician

• Can be taken with or without food, preferably at the same time each day

• Dose adjustments may be necessary based on patient response, blood pressure, and lipid profile

Special Populations:

• Elderly: Start with usual adult dose; monitor for hypotension or statin-related side effects

• Hepatic impairment: Use atorvastatin with caution; monitor liver function

• Renal impairment: No dosage adjustment required for amlodipine; atorvastatin may need monitoring in severe renal dysfunction

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Amdova may interact with:

• Other antihypertensive agents (enhanced blood pressure-lowering effect)

• CYP3A4 inhibitors (may increase atorvastatin levels, risk of myopathy)

• Grapefruit juice (increases atorvastatin bioavailability)

• Drugs affecting liver function or metabolism (e.g., azole antifungals, macrolide antibiotics)

Contraindications

• Known hypersensitivity to amlodipine, atorvastatin, or any excipients

• Active liver disease or unexplained persistent elevations of liver enzymes

• Pregnancy and breastfeeding (atorvastatin is contraindicated)

Side Effects

Common side effects include:

• Amlodipine: Peripheral edema, headache, dizziness, flushing

• Atorvastatin: Muscle pain, fatigue, mild gastrointestinal symptoms, elevated liver enzymes

Rare but serious effects: severe myopathy, rhabdomyolysis, hepatic dysfunction, hypotension

Precautions and Warnings

• Monitor blood pressure and lipid levels regularly

• Periodic liver function tests recommended during atorvastatin therapy

• Caution in patients with severe hepatic impairment, history of statin-induced myopathy, or hypotension

Pregnancy and Lactation

• Pregnancy: Atorvastatin is contraindicated; use amlodipine only if benefit outweighs risk

• Lactation: Avoid during breastfeeding due to atorvastatin excretion in milk

Storage Conditions

Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.