Apuldon Suspension 5 mg/5 ml contains Domperidone Maleate, a dopamine receptor antagonist with prokinetic and antiemetic properties. It is used to relieve nausea and vomiting and to improve stomach motility in patients with delayed gastric emptying (gastroparesis). By promoting faster movement of food through the stomach and intestines, it helps reduce symptoms such as nausea, vomiting, bloating, early fullness, and upper abdominal discomfort.

Domperidone works by blocking dopamine receptors in the gastrointestinal tract and in the chemoreceptor trigger zone (CTZ) of the brain, which is involved in triggering nausea and vomiting. Unlike some other antiemetic medicines, Domperidone has minimal penetration into the central nervous system, reducing the likelihood of certain neurological side effects. It also enhances the contractions of the stomach and upper intestine, facilitating gastric emptying and improving digestive function.

Apuldon Suspension is suitable for adults and children when prescribed by a registered physician. The liquid formulation allows flexible dosing, particularly for children and patients who have difficulty swallowing tablets. Treatment should be used for the shortest duration necessary to control symptoms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 5 ml suspension contains:

• Domperidone Maleate 5 mg

Indications

Apuldon Suspension is indicated for:

• Nausea and vomiting
• Delayed gastric emptying (gastroparesis)
• Functional dyspepsia associated with impaired gastric motility
• Bloating and upper abdominal discomfort
• Early satiety caused by slow stomach emptying

How It Works

Domperidone blocks dopamine receptors in the digestive system and the brain's vomiting center. This action suppresses nausea and vomiting while increasing the movement of the stomach and upper intestines, allowing food to pass more efficiently through the digestive tract.

Dosage & Administration

• Use strictly as prescribed by a registered physician.
• Shake the bottle well before each use.
• Measure the prescribed dose using a calibrated measuring device.
• Take the suspension 15–30 minutes before meals and, if required, before bedtime.
• Do not exceed the recommended dose or duration of treatment.

Possible Side Effects

Some patients may experience:

• Dry mouth
• Abdominal cramps
• Diarrhea
• Headache
• Dizziness
• Drowsiness

Rare but serious side effects include allergic reactions, abnormal heart rhythm (QT prolongation), palpitations, and fainting. Seek immediate medical attention if these occur.

Precautions

• Use cautiously in patients with liver impairment or underlying heart disease.
• Do not exceed the recommended dose, as higher doses may increase the risk of serious cardiac side effects.
• Inform your doctor if you have electrolyte disturbances or a history of irregular heartbeat.
• Use during pregnancy and breastfeeding only if clearly recommended by a healthcare professional.
• Avoid prolonged use unless advised by your physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Apuldon Suspension may interact with:

• Macrolide antibiotics (e.g., erythromycin, clarithromycin)
• Azole antifungal medicines (e.g., ketoconazole, itraconazole)
• Certain antiarrhythmic drugs
• Other medicines that prolong the QT interval
• Dopamine agonists

Always inform your healthcare provider about all prescription medicines, over-the-counter drugs, and herbal supplements you are taking.

Storage

• Store below 30°C.
• Protect from direct sunlight and moisture.
• Keep the bottle tightly closed.
• Keep out of reach of children.