Apaluda Tablet 60 mg contains Apalutamide, a next-generation androgen receptor inhibitor used in the treatment of prostate cancer. It is specifically indicated for patients with non-metastatic castration-resistant prostate cancer (nmCRPC) and metastatic castration-sensitive prostate cancer (mCSPC). Apaluda works by blocking the effect of androgens (male hormones), thereby slowing the growth and spread of prostate cancer cells.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Apalutamide 60 mg per tablet

Mechanism of Action

Apalutamide selectively binds to androgen receptors and inhibits their activity. It prevents androgen receptor translocation to the nucleus, DNA binding, and transcription of androgen-responsive genes. This results in reduced proliferation and increased apoptosis of prostate cancer cells, effectively controlling tumor progression.

Indications

Apaluda Tablet is indicated for:

• Non-metastatic castration-resistant prostate cancer (nmCRPC)
• Metastatic castration-sensitive prostate cancer (mCSPC)
• Use in combination with androgen deprivation therapy (ADT)

Dosage and Administration

• The recommended dose is 240 mg once daily (usually taken as four 60 mg tablets)
• Take orally with or without food
• Swallow tablets whole with water
• Continue treatment as directed by the physician
• Maintain concurrent androgen deprivation therapy unless otherwise advised

Benefits

• Delays disease progression in prostate cancer
• Reduces risk of metastasis
• Improves survival outcomes in appropriate patients
• Well-tolerated oral therapy
• Convenient once-daily dosing

Possible Side Effects

Common side effects may include:

• Fatigue
• Hypertension
• Rash
• Diarrhea
• Weight loss
• Hot flashes

Less common but serious side effects:

• Increased risk of fractures
• Seizures (rare)
• Hypothyroidism
• Cardiovascular complications

Patients should seek immediate medical attention if severe adverse effects occur.

Precautions and Warnings

• Use with caution in patients with a history of seizures or neurological disorders
• Monitor blood pressure, thyroid function, and bone health regularly
• Increased risk of falls and fractures; consider bone-protective measures
• Not indicated for use in women or children
• Effective contraception should be used during treatment and for a period after discontinuation

Drug Interactions

• May interact with drugs metabolized by CYP enzymes
• Can reduce effectiveness of certain medications
• Inform the doctor about all current medications and supplements

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C
• Protect from light and moisture
• Keep out of reach of children

Conclusion

Apaluda Tablet 60 mg (Apalutamide) is an advanced targeted therapy for prostate cancer that effectively delays disease progression and improves patient outcomes. Its precise mechanism and oral administration make it a valuable option in modern cancer management when used under specialist supervision.