Proceptin 40 mg is a proton pump inhibitor (PPI) that effectively reduces stomach acid production. It is widely prescribed for the treatment and prevention of acid-related gastrointestinal disorders, including duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and NSAID-induced ulcers. By targeting the hydrogen-potassium ATPase enzyme in gastric parietal cells, Proceptin 40 mg suppresses acid secretion, providing relief from symptoms such as heartburn, epigastric pain, and acid reflux, while promoting the healing of ulcers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Proceptin 40 mg is indicated for:

• Duodenal and gastric ulcers, including those caused by NSAIDs

• Prevention of NSAID-associated ulcers in patients with a history of ulcer disease

• Gastroesophageal reflux disease (GERD), including maintenance therapy for chronic acid reflux

• Acid-related dyspepsia

• Severe reflux esophagitis with ulcers

• Prophylaxis of acid aspiration during general anesthesia

• Zollinger-Ellison syndrome and other hypersecretory conditions

• Helicobacter pylori eradication as part of combination therapy with appropriate antibiotics

Pharmacology and Mode of Action

Proceptin 40 mg is a benzimidazole derivative that inhibits the H+/K+ ATPase enzyme system in gastric parietal cells. This blockade prevents the final step of acid production, resulting in effective suppression of gastric acid. After oral administration, its antisecretory effects begin within one hour, peak at approximately two hours, and last up to 72 hours. Acid secretion gradually resumes over 3–5 days after discontinuation.

Dosage and Administration

Oral:

• Duodenal ulcer: 20 mg once daily for 4 weeks; increase to 40 mg daily in severe or recurrent cases

• Gastric ulcer: 20 mg once daily for 8 weeks; severe cases may require 40 mg daily

• NSAID-associated ulcers: 20 mg daily for 4–8 weeks; prophylaxis 20 mg once daily

• GERD: 20–40 mg daily for 4–8 weeks; maintenance 20 mg daily

• Dyspepsia: 10–20 mg once daily for 2–4 weeks

• Prophylaxis of acid aspiration: 40 mg evening before and 40 mg 2–6 hours before surgery

• Zollinger-Ellison syndrome: 60 mg daily initially, adjustable 20–120 mg

• H. pylori eradication: 20 mg twice daily in combination with antibiotics

IV Injection:

• 40 mg slow IV over 2–5 minutes for prophylaxis or when oral administration is inappropriate

• Infusion over 20–30 minutes using 100 ml of 5% dextrose or saline

Drug Interactions

• May prolong effects of warfarin, phenytoin, and diazepam; dose adjustments may be necessary

• No significant interaction with theophylline, propranolol, or antacids

Contraindications

• Known hypersensitivity to pantoprazole or any component of the formulation

Side Effects

Proceptin 40 mg is generally well tolerated. Mild side effects may include nausea, abdominal discomfort, headache, dizziness, and paresthesia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Rule out gastric malignancy before starting therapy for suspected ulcers, as PPI therapy may mask symptoms

• Use caution in long-term therapy and monitor for potential vitamin B12 deficiency

Pregnancy and Lactation

• Pregnancy Category C: Observational studies show no adverse effect, but use only if necessary

• Unknown excretion in breast milk; breastfeeding should be discontinued if treatment is required

Storage Conditions

Store in a cool, dry place below 30°C, away from light and moisture. Keep out of reach of children.