Annova Plus Tablet 375 mg+20 mg is a combination medication formulated with Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium, a proton pump inhibitor (PPI). This combination provides effective relief from pain and inflammation while offering protection against gastric irritation and ulcers commonly associated with NSAID therapy. It is particularly useful for patients who require long-term treatment for chronic inflammatory conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Naproxen Sodium 375 mg
• Esomeprazole Magnesium 20 mg

Mechanism of Action

Naproxen Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, reducing the production of prostaglandins that cause pain, swelling, and inflammation.

Esomeprazole Magnesium suppresses gastric acid secretion by inhibiting the proton pump (H+/K+ ATPase) in the stomach lining. This protective action helps reduce the risk of gastric ulcers and irritation caused by prolonged NSAID use.

Indications

Annova Plus Tablet is indicated for:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Chronic musculoskeletal pain
• Long-term pain management in patients at risk of gastrointestinal complications
• Inflammatory joint disorders

Dosage and Administration

• The usual dose is one tablet once daily or as directed by a physician
• Take the tablet at least 30 minutes before meals
• Swallow whole; do not crush, break, or chew
• Follow the prescribed duration for optimal results

Benefits

• Provides effective pain and inflammation relief
• Reduces risk of NSAID-induced gastric ulcers
• Suitable for long-term therapy under medical supervision
• Improves patient compliance with combination formulation
• Offers balanced efficacy with a moderate NSAID dose

Possible Side Effects

Common side effects may include:

• Nausea
• Abdominal discomfort
• Headache
• Diarrhea or constipation
• Flatulence

Less common but serious side effects:

• Gastrointestinal bleeding or ulceration
• Kidney impairment
• Hypersensitivity reactions (rash, swelling, breathing difficulty)
• Long-term risk of vitamin B12 deficiency

Seek immediate medical attention if severe side effects occur.

Precautions and Warnings

• Use cautiously in patients with a history of peptic ulcers or gastrointestinal bleeding
• Monitor kidney and liver function during prolonged use
• Long-term use of PPIs may increase the risk of bone fractures
• Avoid use in severe renal or hepatic impairment unless advised by a doctor
• Not recommended during late pregnancy
• Inform your healthcare provider about any cardiovascular conditions

Drug Interactions

• Increased bleeding risk with anticoagulants (e.g., warfarin)
• Avoid concurrent use with other NSAIDs
• Esomeprazole may alter absorption of certain medications
• Use cautiously with corticosteroids and antiplatelet drugs

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C
• Keep in a dry place, away from light and moisture
• Keep out of reach of children

Conclusion

Annova Plus Tablet 375 mg+20 mg (Naproxen Sodium + Esomeprazole Magnesium) is an effective and well-balanced therapy for managing chronic pain and inflammation while minimizing gastrointestinal risks. It is an ideal option for patients who need sustained NSAID treatment with added stomach protection under medical supervision.