Duovas Tablet 5 mg + 20 mg is a fixed-dose combination of Amlodipine Besilate (5 mg) and Olmesartan Medoxomil (20 mg), formulated for the effective management of hypertension (high blood pressure).

This dual-action therapy combines a calcium channel blocker with an angiotensin II receptor blocker (ARB) to provide enhanced blood pressure control compared to monotherapy. Duovas helps reduce the risk of cardiovascular complications such as stroke, heart attack, and kidney damage, which are commonly associated with uncontrolled hypertension.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Antihypertensive combination therapy

• Calcium Channel Blocker + Angiotensin II Receptor Blocker (ARB)

Pharmacology

Duovas Tablet works through two complementary mechanisms:

Amlodipine Besilate

Amlodipine is a long-acting dihydropyridine calcium channel blocker. It inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. This results in:

• Relaxation of peripheral arteries

• Reduction in systemic vascular resistance

• Lowered blood pressure

• Improved coronary blood flow

Olmesartan Medoxomil

Olmesartan is a selective angiotensin II receptor (AT1) blocker. It prevents angiotensin II from binding to its receptors, thereby:

• Inhibiting vasoconstriction

• Reducing aldosterone secretion

• Lowering sodium and water retention

• Decreasing blood pressure

Together, these agents provide additive antihypertensive effects, improving blood pressure control with a lower risk of dose-related side effects.

Indications

Duovas Tablet 5 mg + 20 mg is indicated for:

• Treatment of essential hypertension

• Patients whose blood pressure is not adequately controlled with monotherapy

• Reduction of cardiovascular risk associated with uncontrolled hypertension

Dosage and Administration

• Recommended dose: One tablet once daily or as prescribed by a physician

• Can be taken with or without food

• Swallow whole with water

• Take at the same time each day for optimal blood pressure control

Dosage adjustments may be required based on individual response and tolerability.

Contraindications

Duovas is contraindicated in patients with:

• Known hypersensitivity to amlodipine, olmesartan, or any component of the tablet

• Severe hepatic impairment

• Severe hypotension

• Pregnancy

• Concomitant use with aliskiren in diabetic patients

Side Effects

Common side effects may include:

• Dizziness

• Peripheral edema (swelling of ankles/feet)

• Headache

• Fatigue

• Flushing

• Nausea

Serious but rare side effects:

• Hypotension

• Hyperkalemia

• Renal impairment

• Allergic reactions

Drug Interactions

• Use caution with other antihypertensive agents (risk of additive hypotension)

• Potassium supplements or potassium-sparing diuretics may increase risk of hyperkalemia

• NSAIDs may reduce antihypertensive effect

• Lithium levels may increase when used with ARBs

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Monitor blood pressure regularly

• Use cautiously in patients with renal artery stenosis, renal impairment, or liver disease

• Risk of symptomatic hypotension in volume-depleted patients

• Monitor serum potassium levels during therapy

Pregnancy and Lactation

• Contraindicated in pregnancy due to risk of fetal injury

• Not recommended during breastfeeding

Storage Conditions

• Store below 30°C

• Protect from light and moisture

• Keep out of reach of children

Mode of Action

Duovas combines arterial vasodilation (Amlodipine) with angiotensin II blockade (Olmesartan), resulting in effective blood pressure reduction, improved vascular function, and reduced cardiovascular risk.