Arlin 100 ml is a synthetic antibacterial agent from the oxazolidinone class of antibiotics, designed to treat serious infections caused by Gram-positive bacteria, including drug-resistant strains. It is highly effective against Vancomycin-Resistant Enterococcus faecium (VRE), methicillin-resistant Staphylococcus aureus (MRSA), and multi-drug resistant Streptococcus pneumoniae. Arlin works by selectively inhibiting bacterial protein synthesis, preventing formation of the 70S initiation complex essential for bacterial growth, making it bacteriostatic for enterococci and staphylococci, and bactericidal for most streptococcal strains.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Oxazolidinone / Macrolide Antibiotic

Indications

Arlin 100 ml is indicated for the treatment of:

• Vancomycin-Resistant Enterococcus faecium (VRE) infections, including concurrent bacteremia

• Nosocomial pneumonia caused by Staphylococcus aureus (MSSA and MRSA) or Streptococcus pneumoniae, including multidrug-resistant strains

• Complicated skin and skin structure infections, including diabetic foot infections (excluding osteomyelitis)

• Uncomplicated skin infections caused by Staphylococcus aureus (MSSA) or Streptococcus pyogenes

• Community-acquired pneumonia, including cases with concurrent bacteremia

Combination therapy may be clinically indicated if Gram-negative pathogens are suspected.

Pharmacology and Mode of Action

Arlin 100 ml binds to the 23S ribosomal RNA of the 50S bacterial subunit, inhibiting formation of the 70S initiation complex. This prevents bacterial protein synthesis, leading to inhibition of bacterial growth or death. Its mechanism differs from other antibiotics, making it effective against resistant Gram-positive pathogens.

• Bacteriostatic: Enterococci and staphylococci

• Bactericidal: Most streptococci

Dosage and Administration

Adults and Adolescents (≥12 years):

• Complicated infections & community-acquired pneumonia: 600 mg IV or oral twice daily for 10–14 days

• Nosocomial pneumonia & VRE infections: 600 mg IV or oral twice daily for 14–28 days

• Uncomplicated skin infections: 400–600 mg oral twice daily for 10–14 days

Pediatric Patients (Birth–11 years):

• IV or oral t.i.d: 10 mg/kg, adjusted by age and infection type

• Neonates (<7 days): 10 mg/kg every 12 hours; may increase to every 8 hours if clinically indicated

Administration:

• Oral Suspension: Reconstitute with boiled and cooled water, shake well before use, store in a cool, dry place, use within 21 days

• IV Infusion: Administer over 30–120 minutes; do not use in series connections; inspect for particulate matter before use

Contraindications

• Hypersensitivity to Arlin or any formulation components

• Concomitant use with MAO inhibitors or within 2 weeks of use

• Patients with uncontrolled hypertension, thyrotoxicosis, pheochromocytoma, carcinoid syndrome, or taking certain adrenergic, serotonergic, or dopaminergic agents

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

• Common: Diarrhea, headache, nausea

• Others: Oral/vaginal moniliasis, hypertension, dyspepsia, abdominal pain, pruritus, tongue discoloration

• Rare: Serotonin syndrome (with concomitant serotonergic agents), convulsions, visual disturbances

Precautions and Warnings

• Monitor for serotonin syndrome when combined with serotonergic drugs

• Evaluate promptly if visual changes or convulsions occur

• Patients with persistent nausea, vomiting, or metabolic abnormalities should be medically assessed

Pregnancy and Lactation

• Pregnancy Category C: Use only if benefits outweigh risks

• Unknown excretion in breast milk; exercise caution when administering to nursing mothers

Storage Conditions

Store at room temperature (15°C–30°C), away from light and moisture. Keep out of reach of children.