Betabis-A Tablet 2.5 mg+5 mg is a fixed-dose combination of Bisoprolol Fumarate and Amlodipine Besilate, formulated for effective management of hypertension and other cardiovascular conditions. This combination brings together a cardio-selective beta-blocker and a calcium channel blocker to provide complementary and sustained blood pressure control while improving overall cardiac function. It is particularly useful for patients who do not achieve adequate control with single-agent therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Bisoprolol Fumarate 2.5 mg

• Amlodipine Besilate 5 mg

Therapeutic Class

• Selective beta-1 adrenergic blocker

• Calcium channel blocker

• Antihypertensive combination

Pharmacology

Bisoprolol Fumarate is a highly selective beta-1 adrenergic receptor blocker that primarily acts on the heart. It reduces heart rate, myocardial contractility, and cardiac output by inhibiting the effects of catecholamines such as adrenaline. This leads to reduced blood pressure and decreased cardiac workload.

Amlodipine Besilate is a dihydropyridine calcium channel blocker that works by inhibiting calcium ion influx into vascular smooth muscle and cardiac muscle cells. This results in relaxation of peripheral blood vessels, reduced peripheral vascular resistance, and improved blood flow.

The combination of bisoprolol and amlodipine provides synergistic antihypertensive effects. While bisoprolol controls heart rate and cardiac output, amlodipine promotes vasodilation, ensuring effective and stable blood pressure reduction throughout the day.

Indications

Betabis-A Tablet 2.5 mg+5 mg is indicated for:

• Management of essential hypertension

• Treatment of chronic stable angina

• Patients requiring combination therapy for optimal blood pressure control

• Reduction of cardiovascular risk associated with elevated blood pressure

Dosage and Administration

• The usual dose is one tablet once daily, preferably taken at the same time each day.

• The tablet should be swallowed whole with water.

• It may be taken with or without food.

• Dosage adjustments should be made gradually under medical supervision.

• Sudden discontinuation, especially of bisoprolol, should be avoided.

Precautions and Warnings

• Use with caution in patients with heart failure, bradycardia, or conduction abnormalities.

• Careful monitoring is required in patients with liver impairment or peripheral vascular disease.

• Bisoprolol may mask symptoms of hypoglycemia and hyperthyroidism.

• Amlodipine should be used cautiously in patients with severe hypotension.

• Use during pregnancy and breastfeeding only if clearly prescribed by a physician.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Some patients may experience:

• Dizziness or fatigue

• Slow heart rate

• Ankle or foot swelling

• Headache or flushing

• Gastrointestinal discomfort

Most side effects are mild and transient. If severe reactions such as fainting, marked swelling, or breathing difficulty occur, medical advice should be sought immediately.

Storage

• Store in a cool, dry place below 30°C.

• Protect from light and moisture.

• Keep out of reach of children.

Conclusion

Betabis-A Tablet 2.5 mg+5 mg offers an effective dual-action approach for the management of hypertension and related cardiovascular conditions. By combining the heart-rate-controlling effect of bisoprolol with the vasodilatory action of amlodipine, it provides reliable blood pressure control and improved cardiovascular protection when used under proper medical supervision.