Bortez Injection 1 mg/vial contains Bortezomib, a proteasome inhibitor used in the treatment of certain blood cancers. It is an important anticancer medicine that helps slow or stop the growth of cancer cells by disrupting their protein degradation system. It is commonly used in combination chemotherapy protocols for hematologic malignancies such as multiple myeloma and mantle cell lymphoma.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Bortezomib 1 mg per vial
• Dosage Form: Sterile powder for injection
• Route: Intravenous or subcutaneous administration (as prescribed)

Mechanism of Action

Bortezomib selectively inhibits the 26S proteasome, a cellular complex responsible for breaking down regulatory proteins. By blocking proteasome activity, abnormal proteins accumulate inside cancer cells, leading to cellular stress and activation of apoptosis (programmed cell death). This results in reduced tumor growth and increased cancer cell death.

Indications

Bortez Injection is indicated for:

• Multiple myeloma
• Mantle cell lymphoma
• Relapsed or refractory plasma cell disorders
• Combination therapy in hematological cancers

Dosage and Administration

• Must be administered under the supervision of an oncologist or qualified healthcare professional
• Dose is determined based on body surface area and treatment regimen
• Given via intravenous bolus or subcutaneous injection
• Treatment cycles are tailored according to patient response and tolerance

Precautions

• Regular monitoring for peripheral neuropathy is required
• Use with caution in patients with liver or kidney impairment
• Frequent blood count monitoring is essential
• Not recommended during pregnancy unless clearly necessary
• Adequate hydration and supportive care may be required during therapy

Side Effects

Common side effects include:

• Fatigue and weakness
• Nausea and vomiting
• Diarrhea or constipation
• Low blood cell counts

Serious side effects:

• Peripheral neuropathy (numbness or tingling in hands and feet)
• Hypotension (low blood pressure)
• Increased risk of infections
• Thrombocytopenia (low platelet count)

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store below 30°C in a cool, dry place
• Protect from light
• Reconstituted solution should be used as directed by medical personnel
• Keep out of reach of children

Conclusion

Bortez Injection 1 mg/vial (Bortezomib) is a potent anticancer agent used primarily in the management of multiple myeloma and other hematological malignancies. It works by targeting cancer cell survival pathways and should only be used under strict medical supervision.