Bupi Heavy Injection 0.5% + 8% is a hyperbaric local anesthetic formulation containing Bupivacaine Hydrochloride 0.5% combined with Dextrose 8%, designed for spinal anesthesia. This solution is heavier than cerebrospinal fluid (CSF) due to the added dextrose, allowing precise control of anesthetic spread within the spinal canal. It provides rapid and long-lasting anesthesia for surgical procedures of the lower abdomen, pelvis, and lower limbs.

Bupivacaine works by blocking sodium ion channels in nerve cells, preventing nerve impulse transmission and thereby inhibiting pain sensation. The hyperbaric property enables anesthesiologists to control the distribution of the anesthetic by patient positioning, ensuring targeted anesthesia with improved safety and efficacy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Provides reliable and long-lasting spinal anesthesia
• Hyperbaric solution allows precise control of anesthetic spread
• Rapid onset of anesthesia for lower abdominal, pelvic, and lower limb surgeries
• Reduces the need for systemic analgesics postoperatively
• Suitable for obstetric and surgical procedures requiring regional anesthesia

Indications

Bupi Heavy Injection 0.5% + 8% is indicated for:

• Spinal anesthesia for lower abdominal surgeries
• Cesarean section and obstetric procedures
• Lower limb orthopedic or surgical procedures
• Situations requiring precise control of anesthetic spread in spinal anesthesia

Mechanism of Action

• Bupivacaine Hydrochloride: Blocks sodium ion channels in neuronal membranes, inhibiting nerve impulse conduction and providing anesthesia and analgesia.
• Dextrose 8%: Increases solution density, making it hyperbaric relative to CSF, which allows anesthesiologists to control the spread of the anesthetic by positioning the patient.

Dosage and Administration

• Administered by trained healthcare professionals only
• Intrathecal injection (spinal anesthesia) using aseptic technique
• Dosage depends on the type and duration of the procedure, patient age, and body weight
• Monitor cardiovascular and respiratory function during and after administration
• Positioning of the patient affects the spread and level of anesthesia

Side Effects

Common side effects:

• Temporary numbness or weakness in the lower body
• Mild hypotension or dizziness
• Transient headache after spinal anesthesia

Rare but serious side effects:

• Severe hypotension, bradycardia, or arrhythmias
• Allergic reactions including rash, swelling, or anaphylaxis
• CNS toxicity such as seizures or confusion in rare cases

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use with caution in patients with cardiovascular, hepatic, or renal impairment
• Avoid intravascular injection
• Ensure resuscitation equipment is available during administration
• Monitor vital signs and neurological status after spinal anesthesia
• Not suitable for patients with known hypersensitivity to amide-type anesthetics

Contraindications

• Hypersensitivity to Bupivacaine or other amide local anesthetics
• Severe cardiovascular instability
• Infection at the injection site or uncontrolled systemic infection

Storage Instructions

• Store below 30°C in a dry place
• Protect from light and contamination
• Keep out of reach of children.