Cytabin Injection 1000 mg/vial contains Cytarabine, a potent antimetabolite chemotherapeutic agent used primarily in the treatment of hematological malignancies. It is a cornerstone drug in modern leukemia chemotherapy protocols. Cytarabine works by inhibiting DNA synthesis in rapidly dividing cancer cells, thereby preventing their proliferation and helping control disease progression.

This high-strength formulation is used in intensive chemotherapy regimens under strict hospital supervision, especially in adult patients requiring high-dose therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Cytarabine 1000 mg

Mechanism of Action

Cytarabine is a pyrimidine nucleoside analog that is converted intracellularly into its active metabolite, cytarabine triphosphate. This active form inhibits DNA polymerase, an enzyme essential for DNA replication. By interfering with DNA synthesis during the S-phase of the cell cycle, Cytarabine blocks cell division and induces apoptosis in rapidly dividing malignant cells, particularly in bone marrow and leukemic cells.

Indications

Cytabin Injection 1000 mg/vial is indicated for the treatment of:

• Acute myeloid leukemia (AML)
• Acute lymphoblastic leukemia (ALL)
• Chronic myelogenous leukemia (blast crisis phase)
• Non-Hodgkin lymphoma (as part of combination chemotherapy)
• Meningeal leukemia (in specialized intrathecal protocols)
• Relapsed or refractory leukemia cases requiring high-dose therapy
• Other hematological malignancies as per oncology guidelines

Dosage and Administration

• Administered only under strict supervision of an oncology specialist
• Routes include intravenous (IV), subcutaneous (SC), or intrathecal (in specialized clinical settings)
• High-dose regimens are typically used in hospital inpatient care
• Dosage is based on body surface area, disease type, and treatment protocol
• Requires intensive monitoring of blood counts and organ function
• Dose adjustments are necessary in hepatic or renal impairment
• Intrathecal administration must be performed only by trained specialists

Contraindications

Cytabin Injection should not be used in:

• Known hypersensitivity to Cytarabine
• Severe bone marrow suppression unless part of controlled chemotherapy protocol
• Active uncontrolled infections without appropriate treatment
• Pregnancy and breastfeeding unless clearly indicated by a specialist

Side Effects

Possible side effects include:

• Severe bone marrow suppression (leukopenia, thrombocytopenia, anemia)
• Nausea, vomiting, and loss of appetite
• Fever and fatigue
• Mouth ulcers (stomatitis)
• Liver enzyme elevation
• Hair loss (alopecia)
• Neurological toxicity at high doses (ataxia, dizziness, confusion)
• Injection site reactions

Precautions

• Intensive blood count and organ function monitoring is essential
• Use cautiously in elderly patients and those with hepatic or renal impairment
• Increased risk of serious infections due to immunosuppression
• Neurological assessment is required during high-dose therapy
• Strict aseptic technique must be followed during administration
• Hospital-based use only under oncology supervision

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Cytabin Injection may interact with:

• Other myelosuppressive agents (increased toxicity)
• Digoxin (reduced therapeutic effect)
• Immunosuppressants (additive immunosuppression)
• Fluorocytosine (reduced antifungal efficacy)

Storage Conditions

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.