Cytosorb Injection (Infusion Set & Surgical Device) is an advanced extracorporeal blood purification therapy designed to reduce excessive inflammatory mediators from the bloodstream. It is primarily used in critically ill patients experiencing severe systemic inflammation, such as in sepsis, septic shock, cytokine storm, severe infections, major surgery, trauma, burns, and acute respiratory distress syndrome (ARDS).

Cytosorb is not a conventional injectable medication; rather, it is a hemoadsorption device used in conjunction with extracorporeal circulation systems such as hemodialysis, continuous renal replacement therapy (CRRT), extracorporeal membrane oxygenation (ECMO), or cardiopulmonary bypass circuits. The device contains highly porous polymer beads that adsorb inflammatory cytokines and other middle-molecular-weight toxins from the blood.

By reducing excessive cytokines, Cytosorb helps stabilize hemodynamics, improve organ function, and support recovery in critically ill patients. It plays a significant role in managing hyperinflammatory states where uncontrolled immune responses can lead to multi-organ failure.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Hemoadsorption Device

• Extracorporeal Blood Purification System

• Surgical and Intensive Care Support Device

Indications

Cytosorb is indicated for use in hospitalized patients requiring extracorporeal blood purification in conditions such as:

• Sepsis and septic shock

• Cytokine release syndrome (CRS)

• Severe systemic inflammatory response syndrome (SIRS)

• Complications following major cardiac or vascular surgery

• Acute respiratory distress syndrome (ARDS)

• Trauma and extensive burns

• Liver failure with elevated inflammatory mediators

It is used under strict medical supervision in intensive care or surgical settings.

Mechanism of Action

Cytosorb works through a process called hemoadsorption:

• Blood is circulated through the extracorporeal circuit

• The blood passes through a cartridge containing biocompatible polymer adsorption beads

• These beads selectively bind and remove excessive cytokines and inflammatory mediators

• The purified blood is then returned to the patient’s circulation

The reduction of inflammatory mediators helps:

• Stabilize blood pressure

• Reduce vasopressor requirements

• Improve organ perfusion

• Support recovery from systemic inflammation

Administration

• Used as part of an extracorporeal circulation system

• Installed by trained healthcare professionals in ICU or operating room settings

• Can be integrated with CRRT, ECMO, or cardiopulmonary bypass circuits

• Duration of use depends on patient condition and clinical response

• Continuous monitoring of hemodynamics and laboratory parameters is required

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Safety and Monitoring

Cytosorb therapy is generally well tolerated when used appropriately. Potential considerations include:

• Monitoring for anticoagulation-related complications

• Observing for hemodynamic instability

• Ensuring correct installation and circuit compatibility

It is not a standalone therapy but part of a comprehensive critical care treatment plan.

Precautions and Warnings

• Must be used only by trained medical personnel

• Not intended for self-administration

• Careful patient selection is required

• Regular monitoring of vital signs, inflammatory markers, and organ function is essential

Storage

• Store in a clean, dry place

• Protect from excessive heat and moisture

• Use before the expiry date mentioned on packaging.