Diasulin Injection 30%+70% is a premixed insulin formulation combining 30% Regular Insulin Human (rapid-acting) and 70% Isophane Insulin Human (NPH, intermediate-acting) at a concentration of 100 IU/ml. This combination provides both rapid postprandial glucose control and extended basal coverage, making it ideal for patients with type 1 or type 2 diabetes mellitus who require balanced insulin therapy. The higher proportion of intermediate-acting insulin ensures longer-lasting basal glycemic control throughout the day.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Regular Insulin Human 30% (rapid-acting)
• Isophane Insulin Human 70% (intermediate-acting)
• Strength: 100 IU/ml

Indications

Diasulin Injection 30%+70% is indicated for:

• Type 1 diabetes mellitus requiring insulin therapy
• Type 2 diabetes mellitus when oral antidiabetic drugs are insufficient
• Management of hyperglycemia in hospitalized patients or those with fluctuating glucose levels
• Patients needing both rapid post-meal and prolonged basal insulin coverage

Mechanism of Action

• Regular Insulin Human: Rapidly lowers blood glucose by promoting cellular uptake of glucose, inhibiting hepatic glucose production, and aiding in protein and lipid metabolism.
• Isophane Insulin Human (NPH): Slowly releases insulin over 12–16 hours, providing basal glucose control.

The 30:70 ratio ensures rapid postprandial glucose control while maintaining stable fasting glucose levels.

Dosage and Administration

• Administer subcutaneously as prescribed by a healthcare professional
• Individualize dose according to blood glucose monitoring, diet, and lifestyle
• Inject before meals for optimal postprandial glucose control
• Rotate injection sites to prevent lipodystrophy
• Do not mix with other insulins unless directed by a physician

Benefits

• Convenient premixed formulation for rapid and basal glucose control
• Reduces the need for multiple daily injections
• Effective management of both postprandial and fasting blood sugar
• Provides longer-lasting basal coverage due to higher proportion of intermediate-acting insulin
• Supports better overall glycemic stability and patient adherence

Side Effects

Common side effects may include:

• Hypoglycemia (low blood sugar)
• Injection site reactions such as redness, swelling, or itching
• Mild weight gain

Rare side effects:

• Severe allergic reactions
• Lipodystrophy at repeated injection sites

Seek immediate medical attention for severe hypoglycemia or allergic reactions.

Precautions

• Monitor blood glucose regularly
• Adjust dose during illness, stress, or changes in diet or activity
• Use cautiously in patients with kidney, liver, or cardiovascular disease
• Keep a source of fast-acting sugar available for hypoglycemia

Contraindications

• Hypersensitivity to insulin or any component of the formulation
• Severe hypoglycemia

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

• May interact with oral antidiabetic agents, corticosteroids, beta-blockers, diuretics, and other medications affecting blood glucose
• Inform your healthcare provider about all medications currently being taken

Storage

• Store refrigerated at 2–8°C; do not freeze
• Protect from heat and light
• Once opened, in-use vials can be stored at room temperature (below 30°C) for up to 28 days
• Keep out of reach of children.