Diplin M Tablet 2.5 mg+500 mg is a combination of Linagliptin and Metformin Hydrochloride used for the management of type 2 diabetes mellitus. This dual-action therapy helps control blood sugar levels more effectively by improving insulin response and reducing glucose production in the liver. It is used along with diet and exercise to achieve optimal glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Diplin M Tablet is indicated for:

• Type 2 diabetes mellitus in adults
• Patients inadequately controlled with diet and exercise alone
• Combination therapy when single agents are insufficient
• Improvement of fasting and post-meal blood glucose levels

Mechanism of Action

This combination works through complementary mechanisms:

Linagliptin:

• DPP-4 inhibitor that increases incretin hormones
• Enhances insulin secretion in response to meals
• Reduces glucagon levels

Metformin Hydrochloride:

• Reduces hepatic glucose production
• Improves insulin sensitivity in peripheral tissues
• Delays intestinal glucose absorption

Together, they provide balanced and effective blood sugar control.

Dosage and Administration

• Dosage should be individualized by a physician
• Commonly taken once or twice daily with meals to reduce gastrointestinal side effects
• Swallow the tablet whole with water
• Do not crush or chew
• Regular blood glucose monitoring is recommended

Benefits

• Dual mechanism for better glycemic control
• Helps reduce both fasting and postprandial blood sugar
• Lower risk of hypoglycemia compared to some other combinations
• Supports long-term diabetes management
• Convenient fixed-dose combination

Possible Side Effects

Common side effects may include:

• Nausea
• Diarrhea
• Abdominal discomfort
• Headache
• Upper respiratory tract infections

Serious but rare side effects:

• Lactic acidosis (associated with metformin)
• Pancreatitis
• Vitamin B12 deficiency (long-term use)

Seek immediate medical attention if severe symptoms occur.

Precautions and Warnings

• Not recommended for type 1 diabetes or diabetic ketoacidosis
• Use cautiously in patients with kidney or liver impairment
• Monitor renal function regularly
• Avoid excessive alcohol consumption (increases risk of lactic acidosis)
• Use during pregnancy or breastfeeding only if prescribed

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Diplin M Tablet may interact with:

• Alcohol (increased risk of lactic acidosis)
• Iodinated contrast agents
• Other antidiabetic drugs (risk of hypoglycemia)
• Rifampicin (may reduce linagliptin effectiveness)

Always inform your healthcare provider about all medications and supplements.

Storage

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children.