Emistat Injection 8 mg/4 ml contains Ondansetron. It is a fast-acting injectable medication commonly used in hospital and clinical settings to control nausea and vomiting associated with surgery, chemotherapy, and radiotherapy.

The injectable form is particularly useful when oral administration is not possible or when rapid relief is required.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each 4 ml ampoule contains:

• Ondansetron 8 mg

For intravenous (IV) or intramuscular (IM) administration.

Mechanism of Action

Ondansetron works by blocking serotonin-mediated pathways:

• It is a selective 5-HT3 receptor antagonist
• Blocks serotonin receptors in both the central nervous system and gastrointestinal tract
• Prevents stimulation of the vomiting center in the brain
• Effectively controls both acute and delayed nausea and vomiting

Indications

Emistat Injection is indicated for:

• Nausea and Vomiting
• Chemotherapy-induced nausea and vomiting (CINV)
• Radiation-induced nausea and vomiting
• Postoperative nausea and vomiting (PONV)
• Severe vomiting when oral therapy is not feasible

Dosage and Administration

• Administered by a qualified healthcare professional
• Given via slow IV injection, IV infusion, or IM injection
• Dose depends on patient condition, age, and clinical indication
• Often given before chemotherapy, surgery, or radiation therapy

Benefits

Emistat Injection offers several advantages:

• Rapid onset of action
• Effective in severe or persistent vomiting
• Suitable when oral intake is not possible
• Reliable control of treatment-related nausea
• Well established safety profile in clinical use

Possible Side Effects

Common side effects include:

• Headache
• Constipation
• Flushing
• Injection site reactions

Less common side effects:

• Dizziness
• Fatigue
• Mild hypotension

Rare but serious side effects:

• QT Prolongation
• Severe allergic reactions (anaphylaxis)
• Cardiac arrhythmias

Precautions

• Use cautiously in patients with heart rhythm disorders
• Monitor electrolyte levels (especially potassium and magnesium)
• Avoid rapid IV administration (to reduce cardiac risk)
• Inform healthcare providers about all current medications
• Use in pregnancy or breastfeeding only if clearly needed

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Ondansetron may interact with:

• QT-prolonging drugs (e.g., certain antiarrhythmics)
• Antidepressants (risk of serotonin syndrome)
• Apomorphine (contraindicated)

Storage

Store below 30°C, protected from light. Do not freeze. Keep out of reach of children.