Esipram 5 mg is an antidepressant medication containing escitalopram, a highly selective serotonin reuptake inhibitor (SSRI). It is widely prescribed for the management of mood and anxiety-related disorders. By restoring the balance of serotonin in the brain, Esipram 5 mg helps improve mood, reduce anxiety, and enhance overall emotional well-being. Due to its favorable tolerability profile, it is commonly used for both short-term and long-term treatment under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Esipram 5 mg is indicated in the treatment of:

• Depressive illness

• Generalized anxiety disorder

• Obsessive-compulsive disorder

• Social anxiety disorder

Therapeutic Class

• SSRIs & related anti-depressant drugs

Pharmacology

Esipram 5 mg acts as a selective inhibitor of serotonin (5-hydroxytryptamine, 5-HT) reuptake in the central nervous system. By blocking the reuptake of serotonin into presynaptic neurons, it increases serotonin availability in the synaptic cleft, enhancing serotonergic neurotransmission. This mechanism is responsible for its antidepressant and anxiolytic effects. Esipram 5 mg has minimal or no affinity for other receptors, including dopamine, adrenergic, histaminergic, muscarinic, benzodiazepine, and opioid receptors, which contributes to its lower incidence of unwanted side effects compared to older antidepressants.

Dosage and Administration

• Adults: The usual initial dose is 10 mg once daily. Based on clinical response and tolerability, the dose may be increased to a maximum of 20 mg daily after at least one week.

• Panic disorder: Adults may start with 5 mg once daily, increased to 10 mg after 7 days. The maximum dose is 20 mg daily.

• Social anxiety disorder: Adults typically start at 10 mg once daily. Dose adjustments may be made after 2–4 weeks, with a usual range of 5–20 mg daily.

• Elderly: A recommended dose of 10 mg once daily is generally sufficient. Lower maintenance doses may be appropriate.

Esipram 5 mg should be taken orally once daily, with or without food, as directed by a physician.

Drug Interactions

• Concomitant use with monoamine oxidase inhibitors (MAOIs) is contraindicated

• Esipram 5 mg should not be started until at least 2 weeks after stopping an MAOI

• MAOIs should not be initiated until at least one week after discontinuing Esipram 5 mg

Contraindications

Esipram 5 mg is contraindicated in patients with:

• Concomitant use of MAOIs

• Concomitant use of pimozide

• Known hypersensitivity to escitalopram, citalopram, or any excipients

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Esipram 5 mg is generally well tolerated. Common side effects may include:

• Nausea

• Insomnia or drowsiness

• Increased sweating

• Fatigue

• Sexual dysfunction, including problems with ejaculation

Most side effects are mild, transient, and tend to resolve with continued treatment.

Pregnancy and Lactation

• Pregnancy: Safety during pregnancy has not been fully established. Use only if the potential benefit justifies the potential risk to the fetus.

• Lactation: Esipram 5 mg is excreted in breast milk. Use during breastfeeding only if clearly necessary and advised by a physician.

Precautions and Warnings

Abrupt discontinuation may lead to withdrawal symptoms such as dizziness, irritability, anxiety, headache, insomnia, and sensory disturbances. Gradual dose reduction is recommended when discontinuing therapy. Patients should be monitored closely during dose changes or discontinuation.

Storage Conditions

• Store in a cool and dry place below 30°C

• Protect from light