Esonix M 20 mg is a proton pump inhibitor (PPI) formulated to effectively suppress gastric acid secretion. It is used in the treatment and prevention of various acid-related gastrointestinal disorders. By providing prolonged inhibition of gastric acid production, Esonix M 20 mg helps relieve symptoms, promotes healing of damaged mucosa, and reduces the risk of ulcer recurrence in patients requiring acid suppression therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Esonix M 20 mg is indicated for the treatment of:

• Gastroesophageal Reflux Disease (GERD)

• Healing of erosive esophagitis

• Maintenance of healing of erosive esophagitis

• Symptomatic GERD

• Reduction of NSAID-associated gastric ulcers

• Helicobacter pylori eradication as part of triple therapy

• Zollinger–Ellison syndrome

Therapeutic Class

Proton Pump Inhibitor

Pharmacology

Esonix M 20 mg suppresses gastric acid secretion by irreversibly inhibiting the H⁺/K⁺-ATPase enzyme system located on the secretory surface of gastric parietal cells. It covalently binds to sulfhydryl groups of cysteine residues on the proton pump, thereby blocking the final step of acid production. This mechanism results in inhibition of both basal and stimulated acid secretion, regardless of the stimulus. Because acid secretion resumes only after new enzyme synthesis, the antisecretory effect of Esonix M 20 mg lasts longer than 24 hours.

Dosage and Administration

Tablet or Capsule

Healing of Erosive Esophagitis

• 20 mg or 40 mg once daily for 4–8 weeks

• An additional 4–8 weeks may be considered if healing is incomplete

Maintenance of Healing of Erosive Esophagitis

• 20 mg once daily

• Controlled studies did not extend beyond 6 months

Symptomatic GERD

• 20 mg once daily for 4 weeks

• Treatment may be extended for another 4 weeks if symptoms persist

H. pylori Eradication (Triple Therapy)

• Esonix M 20 mg: 20 mg twice daily for 10 days

• Amoxicillin: 1000 mg twice daily for 10 days

• Clarithromycin: 500 mg twice daily for 10 days

Injection (IV Use)

• 20 mg or 40 mg once daily by slow intravenous injection (minimum 3 minutes) or intravenous infusion (10–30 minutes) in GERD with erosive esophagitis

Method of Administration

Intravenous Infusion Preparation

• Reconstitute one vial with 5 ml of 0.9% sodium chloride

• Further dilute to a final volume of 50 ml (final concentration: 0.8 mg/ml)

Administration

• 20 mg dose: Withdraw 25 ml and infuse over 10–30 minutes

• 10 mg dose: Withdraw 12.5 ml and infuse over 10–30 minutes

Drug Interactions

• Esonix M 20 mg selectively inhibits the cytochrome P450 mono-oxygenase system

• Clinically significant drug interactions have not been commonly reported

• Reduction in gastric acid may affect vitamin B12 absorption and gastric bacterial colonization

• Possible interaction with oral combined contraceptives cannot be fully excluded

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Known hypersensitivity to Esonix M 20 mg or any component of the formulation

Side Effects

Reported side effects include:

• Headache

• Diarrhea

• Abdominal pain

Pregnancy and Lactation

Esonix M 20 mg is classified as US FDA Pregnancy Category C. It should be avoided during pregnancy and lactation unless the potential benefits outweigh the possible risks to the fetus or infant.

Precautions and Warnings

• Malignancy should be excluded in patients with suspected gastric ulcer before initiating therapy

• When used with antibiotics, consult the prescribing information of the respective antibacterial agents

Storage Conditions

• Store in a dry place

• Protect from light and heat

• Keep out of reach of children

Reconstitution

For injection, reconstitute the vial with 5 ml of 0.9% sodium chloride for intravenous use. The resulting solution should be clear and colorless to slightly yellow before administration.