Eval CR Tablet 200 mg is a controlled-release formulation containing Sodium Valproate, a widely used anticonvulsant and mood-stabilizing agent. It is primarily indicated for the treatment of epilepsy, including generalized tonic-clonic seizures, absence seizures, and complex partial seizures. Additionally, it is prescribed for bipolar disorder to manage manic episodes and stabilize mood, as well as for migraine prophylaxis in adults and adolescents.

The controlled-release (CR) technology allows gradual absorption of the medication over an extended period, providing more stable blood levels, reducing fluctuations, and minimizing peak-related side effects. This formulation supports once or twice-daily dosing, improving patient adherence and convenience, particularly for long-term therapy.

Epilepsy is a neurological disorder caused by abnormal electrical activity in the brain, leading to recurrent seizures. Without effective control, seizures can impair daily functioning, cognitive performance, and overall quality of life. Eval CR Tablet 200 mg helps stabilize neuronal activity, reduce seizure frequency, and improve patient well-being.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Features and Benefits

Active Ingredient:

• Sodium Valproate 200 mg per controlled-release tablet

Effective Seizure Control:

• Reduces the frequency and severity of generalized and partial seizures

• Controls absence and complex seizure types

• Suitable as monotherapy or adjunctive therapy

Mood Stabilization:

• Helps manage manic and mixed episodes in bipolar disorder

• Reduces emotional instability and mood swings

• Supports better overall mental health

Migraine Prophylaxis:

• Reduces frequency, duration, and intensity of migraine attacks

• Helps improve daily functioning and comfort

Controlled-Release Technology:

• Provides steady release of medication over time

• Minimizes peak-related side effects like dizziness and drowsiness

• Reduces the need for frequent dosing, improving adherence

How It Works

Sodium Valproate works through multiple mechanisms to regulate brain activity:

1. Enhances GABA activity: Increases levels of gamma-aminobutyric acid (GABA), the brain’s inhibitory neurotransmitter, reducing excessive neuronal firing.

2. Modulates ion channels: Blocks voltage-gated sodium and calcium channels, preventing abnormal electrical discharges.

3. Neuroprotective effects: Protects neurons from excitotoxic damage associated with repeated seizures.

The controlled-release mechanism ensures a steady plasma concentration, which enhances therapeutic efficacy while minimizing side effects.

Indications

Eval CR Tablet 200 mg is indicated for:

• Generalized tonic-clonic seizures

• Absence seizures

• Complex partial seizures

• Bipolar disorder (manic and mixed episodes)

• Migraine prophylaxis

Dosage and Administration

• Take orally as directed by a physician, preferably with food to reduce gastrointestinal discomfort.

• Do not crush, chew, or break the tablet, as this will compromise the controlled-release mechanism.

• The dosage is individualized based on clinical response, age, and body weight.

• Regular monitoring of liver function, blood counts, and plasma levels is recommended during long-term therapy.

• Do not abruptly discontinue therapy to avoid seizure recurrence or mood destabilization.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Safety Information

• Inform your doctor of any liver disease, kidney impairment, history of pancreatitis, or hematological disorders.

• Common side effects include nausea, vomiting, dizziness, drowsiness, tremor, and weight gain.

• Rare but serious adverse effects include hepatotoxicity, pancreatitis, thrombocytopenia, and severe allergic reactions. Seek immediate medical attention if these occur.

• Avoid alcohol, as it can enhance drowsiness and impair seizure control.

• Use caution when performing tasks requiring alertness, such as driving or operating machinery.

Storage Instructions

• Store below 30°C in a cool, dry place.

• Protect from light and moisture.

• Keep out of reach of children.

Eval CR Tablet 200 mg offers effective seizure control, mood stabilization, and migraine prevention through its controlled-release mechanism. Its steady plasma levels, convenient dosing, and reliable therapeutic action make it suitable for long-term management of epilepsy, bipolar disorder, and migraine prophylaxis under medical supervision.