Frehepta Tablet 60 mg contains Resmetirom, a selective thyroid hormone receptor-β (THR-β) agonist, developed for the treatment of non-alcoholic steatohepatitis (NASH) and other metabolic liver disorders. By targeting liver-specific thyroid hormone pathways, Resmetirom helps reduce liver fat, improve lipid metabolism, and potentially slow disease progression. Frehepta is intended for patients with fatty liver disease associated with metabolic syndrome, obesity, or dyslipidemia.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Frehepta 60 mg is indicated for:

• Treatment of non-alcoholic steatohepatitis (NASH) in adults

• Reduction of hepatic steatosis and liver inflammation associated with metabolic disorders

• Potential improvement of liver function tests in patients with metabolic-associated fatty liver disease

This medication is particularly suited for patients at risk of NASH progression, including those with elevated liver enzymes, insulin resistance, or hyperlipidemia.

Therapeutic Class

Selective Thyroid Hormone Receptor-β Agonist

Pharmacology

Resmetirom selectively activates thyroid hormone receptor-β (THR-β) in the liver, leading to multiple beneficial metabolic effects:

• Reduction of hepatic fat accumulation: Stimulates lipid metabolism and beta-oxidation in hepatocytes, reducing liver fat content

• Improvement in lipid profile: Lowers serum LDL cholesterol and triglyceride levels

• Anti-inflammatory and antifibrotic effects: Modulates hepatic gene expression to reduce inflammation and slow fibrosis progression

Unlike non-selective thyroid hormone therapies, Resmetirom minimizes systemic effects on heart rate and bone, offering targeted liver benefits with an improved safety profile.

Dosage & Administration

Frehepta Tablet 60 mg is administered orally as prescribed by a physician.

• The typical dose is 60 mg once daily

• Swallow the tablet whole with water, preferably at the same time each day

• Dosage may be adjusted by the physician based on clinical response and tolerability

• Regular monitoring of liver function tests and lipid profile is recommended

Patients should maintain a healthy lifestyle, including a balanced diet and regular exercise, to maximize therapeutic benefits.

Drug Interactions

• Resmetirom may interact with strong CYP3A4 inhibitors or inducers, potentially altering plasma concentrations

• Concomitant use with other thyroid hormone therapies requires caution to avoid systemic effects

• Lipid-lowering agents or other hepatoprotective medications may be used concurrently under medical supervision

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

Frehepta 60 mg is contraindicated in patients with:

• Hypersensitivity to Resmetirom or any excipient in the tablet

• Uncontrolled thyroid disorders

• Severe cardiovascular disease without medical supervision

Side Effects

Frehepta 60 mg is generally well tolerated. Common side effects may include:

• Mild headache

• Gastrointestinal disturbances, such as nausea or diarrhea

• Fatigue

• Transient changes in thyroid function tests

Serious adverse reactions are rare but may include palpitations or arrhythmias in susceptible individuals. Patients should report any unusual symptoms promptly.

Pregnancy & Lactation

The safety of Frehepta during pregnancy and breastfeeding has not been fully established. It should only be used when the potential benefits outweigh the risks, under strict medical supervision.

Precautions & Warnings

• Regular monitoring of liver function, lipid profile, and thyroid function is recommended during treatment

• Use caution in patients with pre-existing cardiovascular disease

• Not recommended for use in pediatric populations or in patients with severe renal impairment without physician guidance

Storage Conditions

Store below 30°C, protected from light and moisture. Keep out of the reach of children.

Mode of Action

Resmetirom in Frehepta selectively activates thyroid hormone receptor-β in the liver, enhancing lipid metabolism, reducing hepatic fat accumulation, and improving liver function while minimizing systemic thyroid-related effects.