Gemzen Injection 1 gm/26.3 ml contains Gemcitabine, a potent antineoplastic agent widely used in the treatment of various solid tumors. It is supplied as a sterile solution for intravenous administration and is used under the supervision of qualified oncology specialists. Gemzen Injection plays an important role in modern chemotherapy regimens, either as monotherapy or in combination with other anticancer agents.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Gemcitabine 1 gm per 26.3 ml injection

Therapeutic Class

• Antineoplastic agent

• Pyrimidine antimetabolite

Indications

Gemzen Injection is indicated for the treatment of several malignancies, including:

• Non-small cell lung cancer

• Pancreatic cancer

• Breast cancer

• Ovarian cancer

• Bladder cancer

It may be used alone or in combination with other chemotherapy drugs depending on the type and stage of cancer, as well as patient-specific factors.

Mechanism of Action

Gemcitabine is a nucleoside analogue of deoxycytidine. After intravenous administration, it is metabolized intracellularly into active diphosphate and triphosphate forms. These active metabolites inhibit DNA synthesis by blocking ribonucleotide reductase and by incorporating into DNA strands, leading to termination of DNA chain elongation. This process prevents cancer cell replication and promotes programmed cell death, thereby slowing tumor growth and spread.

Dosage and Administration

• Gemzen Injection is administered intravenously, usually as an infusion over 30 minutes.

• Dosage and treatment schedules vary depending on the type of cancer, treatment protocol, body surface area, and patient tolerance.

• Treatment should only be initiated and monitored by experienced healthcare professionals in oncology settings.

Dose adjustments may be required based on blood counts, liver function, kidney function, and overall clinical condition.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Elderly Patients: Dose adjustment may be required based on tolerance and organ function.

• Hepatic or Renal Impairment: Use with caution and close monitoring.

• Pregnancy and Lactation: Contraindicated due to potential risk to the fetus and infant.

Side Effects

Commonly reported side effects of Gemzen Injection include:

• Bone marrow suppression (anemia, leukopenia, thrombocytopenia)

• Nausea and vomiting

• Fatigue and weakness

• Fever and flu-like symptoms

• Elevated liver enzymes

• Skin rash and hair loss

Serious adverse effects may occur and require immediate medical attention.

Drug Interactions

Gemcitabine may interact with:

• Other cytotoxic chemotherapy agents

• Radiotherapy, which may increase toxicity

• Live vaccines, which should be avoided during treatment

All concurrent medications should be reviewed by the treating physician.

Storage

• Store as directed by the manufacturer

• Protect from light

• Keep out of reach of children

• Do not freeze unless specified

Advantages of Gemzen Injection

• Proven efficacy against multiple solid tumors

• Can be used as monotherapy or in combination regimens

• Well-established role in oncology treatment protocols

• Flexible dosing schedules based on clinical needs.