Gliclid MR Tablet 30 mg is a modified-release oral antidiabetic medication containing Gliclazide, a sulfonylurea class agent used in the management of type 2 diabetes mellitus. This MR (Modified Release) formulation ensures gradual and prolonged release of Gliclazide over 24 hours, providing stable blood glucose control with a once-daily dose.

Gliclid MR Tablet 30 mg is particularly useful for patients whose diabetes cannot be adequately controlled by diet and lifestyle measures alone. By stimulating insulin secretion from pancreatic beta cells, it helps lower both fasting and postprandial blood glucose levels, reducing the risk of long-term complications such as neuropathy, nephropathy, and cardiovascular disease.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Gliclid MR Tablet 30 mg is indicated for:

• Type 2 diabetes mellitus (non-insulin-dependent diabetes)

• Patients requiring long-acting glycemic control through a once-daily medication

• Adjunctive therapy when diet, exercise, and lifestyle modifications are insufficient

• Can be used alone or in combination with other oral hypoglycemic agents, as prescribed by a physician

It is not suitable for type 1 diabetes or for treating diabetic ketoacidosis.

Mechanism of Action

• Pancreatic stimulation: Gliclazide binds to sulfonylurea receptors on beta cells, leading to closure of ATP-sensitive potassium channels.

• Insulin release: Membrane depolarization triggers calcium influx, stimulating insulin secretion into the bloodstream.

• Modified-release advantage: The MR formulation provides slow and steady release, maintaining stable blood glucose levels throughout the day.

• Glucose-dependent action: Reduces the risk of hypoglycemia compared to non-selective sulfonylureas.

• Vascular protection: Gliclazide exhibits antioxidant and microvascular protective effects, helping prevent diabetes-related vascular complications.

Dosage and Administration

• Adults: Typically, 1 tablet once daily, preferably with breakfast to reduce the risk of hypoglycemia.

• Dose adjustment: May be increased gradually based on blood glucose monitoring, up to the maximum recommended daily dose as advised by a physician.

• Monitoring: Regular blood glucose and HbA1c testing is recommended to assess efficacy.

• Swallow the tablet whole with water, without crushing or chewing, to maintain the modified-release properties.

• Continue dietary and lifestyle interventions for optimal glycemic control.

Benefits and Features

• Provides long-acting, stable glycemic control with once-daily dosing

• Reduces fasting and postprandial blood glucose levels

• Minimizes risk of hypoglycemia due to glucose-dependent insulin release

• Exhibits antioxidant and vascular protective effects

• Can be used alone or in combination therapy

• Supports long-term management of type 2 diabetes

Side Effects

Gliclid MR Tablet 30 mg is generally well tolerated. Possible side effects include:

• Hypoglycemia, especially if meals are skipped or delayed

• Mild gastrointestinal disturbances such as nausea, vomiting, or stomach upset

• Rare allergic reactions like rash, itching, or photosensitivity

• Very rarely, blood disorders such as thrombocytopenia

Patients should monitor blood glucose levels and consult a doctor if adverse reactions persist or worsen.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis

• Use cautiously in elderly patients due to hypoglycemia risk

• Alcohol may increase hypoglycemia risk

• Inform healthcare providers about other medications to prevent interactions

• Maintain diet, exercise, and regular monitoring alongside therapy

Storage Conditions

Store Gliclid MR Tablet 30 mg in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children.

Gliclid MR Tablet 30 mg is a safe and effective long-acting oral antidiabetic agent that helps maintain stable blood glucose, support pancreatic function, and reduce the risk of diabetes-related complications, making it ideal for adults requiring convenient once-daily glycemic control.