Gliclid Tablet 80 mg contains Gliclazide, a sulfonylurea class oral hypoglycemic agent, specifically formulated for the management of type 2 diabetes mellitus. It works by stimulating the beta cells of the pancreas to release insulin, thereby helping to control blood glucose levels in adults with non-insulin-dependent diabetes.

Gliclid Tablet 80 mg is particularly effective for patients whose diabetes cannot be managed by diet, exercise, and lifestyle modifications alone. It helps maintain glycemic control, reducing the risk of long-term complications associated with diabetes, such as cardiovascular disease, kidney damage, and neuropathy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Gliclid Tablet 80 mg is indicated for:

• Type 2 diabetes mellitus (non-insulin-dependent diabetes)

• Adjunctive therapy when diet, exercise, and lifestyle changes alone are insufficient to control blood glucose

• Can be used alone or in combination with other oral antidiabetic agents, depending on glycemic response

It is not intended for the treatment of type 1 diabetes or diabetic ketoacidosis.

Mechanism of Action

• Insulin secretion stimulation: Gliclazide binds to sulfonylurea receptors on pancreatic beta cells, leading to the closure of ATP-sensitive potassium channels.

• This action depolarizes the beta cell membrane, opening calcium channels, which triggers insulin release into the bloodstream.

• Selective effect: Gliclazide has a glucose-dependent action, which helps reduce the risk of hypoglycemia compared to other sulfonylureas.

• Improved microcirculation: Gliclazide also exhibits antioxidant and vascular protective properties, helping reduce vascular complications associated with diabetes.

Dosage and Administration

• Adults: The usual starting dose is 40–80 mg once daily, taken with breakfast or the first main meal to minimize the risk of hypoglycemia.

• Depending on glycemic control, the dose may be adjusted up to 320 mg daily, divided into two doses if required.

• Monitoring: Regular blood glucose monitoring is recommended to evaluate the effectiveness and adjust dosage accordingly.

• Take the tablet whole with water, without crushing or chewing.

• Maintain dietary and lifestyle measures alongside medication for optimal results.

Benefits and Features

• Effectively lowers fasting and postprandial blood glucose levels

• Glucose-dependent insulin release reduces hypoglycemia risk

• Can be used alone or in combination with other antidiabetic agents

• Exhibits antioxidant and vascular protective effects

• Helps prevent long-term diabetic complications when combined with lifestyle management

Side Effects

Gliclid Tablet 80 mg is generally well tolerated. Common side effects may include:

• Hypoglycemia (low blood sugar), particularly if meals are skipped

• Gastrointestinal disturbances such as nausea, vomiting, or abdominal discomfort

• Rare allergic reactions like rash, itching, or photosensitivity

• Very rarely, hematologic abnormalities such as thrombocytopenia

Patients should monitor blood glucose levels regularly and report persistent or severe side effects to a healthcare provider.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Not recommended for type 1 diabetes, diabetic ketoacidosis, or severe kidney/liver impairment

• Use with caution in elderly patients due to increased hypoglycemia risk

• Alcohol may increase the risk of hypoglycemia and adverse effects

• Inform your doctor of all medications to avoid drug interactions

• Maintain regular diet and exercise alongside therapy

Storage Conditions

Store Gliclid Tablet 80 mg in a cool, dry place below 25°C, away from direct sunlight and moisture. Keep out of reach of children.

Gliclid Tablet 80 mg is an effective and reliable oral hypoglycemic agent that helps control blood glucose, support pancreatic function, and reduce the risk of diabetic complications, making it suitable for adults with type 2 diabetes requiring consistent glycemic management.