Glipita M XR Tablet 50 mg+1000 mg is a fixed-dose combination of Sitagliptin and Metformin Hydrochloride (Extended Release), developed for the effective and sustained control of type 2 diabetes mellitus in adult patients. This formulation is particularly suitable for individuals who require a higher dose of metformin to achieve optimal glycemic control while benefiting from the complementary action of sitagliptin.

The extended-release (XR) formulation of metformin allows gradual drug release over time, ensuring prolonged glucose-lowering action, improved gastrointestinal tolerability, and convenient once-daily dosing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

DPP-4 Inhibitor + Biguanide (Antidiabetic Combination)

Pharmacology

Sitagliptin is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor that increases circulating levels of incretin hormones, including GLP-1 and GIP. These hormones enhance glucose-dependent insulin secretion from pancreatic beta cells and suppress glucagon release from alpha cells, leading to reduced hepatic glucose production and improved fasting and postprandial blood glucose control.

Metformin Hydrochloride acts primarily by decreasing hepatic gluconeogenesis, improving insulin sensitivity in peripheral tissues, and reducing intestinal absorption of glucose. The extended-release formulation provides steady plasma concentrations, minimizes peak-related side effects, and improves patient compliance.

Together, sitagliptin and metformin provide complementary and synergistic effects on blood glucose regulation without significantly increasing the risk of hypoglycemia when used appropriately.

Indications

Glipita M XR Tablet 50 mg+1000 mg is indicated for:

• Treatment of type 2 diabetes mellitus in adults

• Patients inadequately controlled on lower-dose metformin or combination therapy

• Adjunct therapy to diet and exercise for improved glycemic control

Dosage and Administration

The usual recommended dose is one tablet once daily, preferably taken with the evening meal. The tablet should be swallowed whole and must not be crushed, split, or chewed. Dose selection should be individualized based on glycemic response, previous therapy, and renal function, as advised by a physician.

Benefits and Features

• Higher-strength metformin for enhanced glucose control

• Dual mechanism of action targeting multiple pathways

• Extended-release formulation for improved tolerability

• Low risk of hypoglycemia

• Once-daily dosing improves treatment adherence

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Renal impairment: Contraindicated in severe renal dysfunction; careful monitoring required in moderate impairment

• Elderly patients: Renal function assessment is recommended before and during treatment

• Pregnancy and lactation: Use only when clearly needed and under medical supervision

Side Effects

Common side effects may include:

• Gastrointestinal disturbances such as nausea or diarrhea

• Headache

• Upper respiratory tract infections

• Metallic taste

Rare but serious reactions such as lactic acidosis or pancreatitis require immediate medical attention.

Precautions and Warnings

• Not suitable for type 1 diabetes or diabetic ketoacidosis

• Regular monitoring of blood glucose and renal function is essential

• Temporary discontinuation may be required during major surgery or contrast imaging procedures

Storage

Store in a cool and dry place below 30°C. Protect from light and moisture. Keep out of reach of children.