Itrazen Tablet 200 mg contains Itraconazole, a broad-spectrum antifungal medicine used for the treatment of various fungal infections affecting the skin, nails, respiratory system, and internal organs. It is effective in both superficial and systemic fungal infections and is commonly prescribed for resistant or recurrent fungal conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each tablet contains:

• Itraconazole 200 mg

Mechanism of Action

Itraconazole works by inhibiting the fungal enzyme lanosterol 14-α-demethylase, which is essential for ergosterol synthesis. Ergosterol is a vital component of fungal cell membranes. By blocking its production, Itraconazole disrupts membrane integrity, leading to inhibition of fungal growth and eventual cell death.

Indications

Itrazen Tablet 200 mg is indicated for:

• Dermatophytosis (ringworm infections)
• Onychomycosis (fungal nail infections)
• Oral and esophageal candidiasis
• Aspergillosis and other systemic fungal infections
• Fungal infections in immunocompromised patients
• Chronic or recurrent fungal infections

Dosage and Administration

• To be taken orally as prescribed by a physician
• Usually taken after meals for better absorption
• Dosage and duration depend on infection type and severity
• Tablets should be swallowed whole with water
• Complete the full course even if symptoms improve early

Contraindications

Itrazen Tablet should not be used in:

• Known hypersensitivity to Itraconazole
• Patients with severe heart failure (contraindicated)
• Severe liver disease without medical supervision
• Concomitant use with certain drugs metabolized by CYP3A4 (restricted combinations)

Side Effects

Possible side effects include:

• Nausea and vomiting
• Abdominal discomfort
• Headache
• Dizziness
• Skin rash
• Elevated liver enzymes

Serious side effects may include:

• Hepatotoxicity
• Heart failure exacerbation (rare but serious)

Precautions

• Liver function should be monitored during long-term therapy
• Use cautiously in patients with cardiac disease
• Avoid alcohol to reduce liver toxicity risk
• Take after meals for improved absorption
• Not recommended during pregnancy unless clearly advised by a physician

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Itrazen Tablet may interact with:

• CYP3A4 substrate drugs (significant interactions)
• Statins (risk of toxicity)
• Anticoagulants
• Antiarrhythmic medicines
• Benzodiazepines and other sedatives

Storage Conditions

• Store below 30°C in a dry place
• Protect from moisture and light
• Keep out of reach of children.