Kilbac 125 mg/5 ml is an oral antibiotic suspension containing Cefuroxime, a second-generation cephalosporin. It is widely used for the treatment of a broad range of bacterial infections caused by susceptible organisms. Cefuroxime is known for its strong bactericidal activity and stability against β-lactamase–producing bacteria, making it effective where resistance to older antibiotics may exist. This formulation is particularly suitable for pediatric patients and individuals who prefer liquid dosage forms.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

Second Generation Cephalosporins

Indications

Kilbac 125 mg/5 ml is indicated for the treatment of infections caused by sensitive bacteria, including:

• Upper Respiratory Tract Infections

  • Pharyngitis and tonsillitis caused by Streptococcus pyogenes

  • Acute bacterial maxillary sinusitis caused by Streptococcus pneumoniae or Haemophilus influenzae (non β-lactamase producing strains)

• Ear Infections

  • Acute bacterial otitis media caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis (β-lactamase producing strains), or Streptococcus pyogenes

• Lower Respiratory Tract Infections

  • Community-acquired pneumonia

  • Acute bacterial exacerbation of chronic bronchitis

  • Secondary bacterial infections of acute bronchitis
    Caused by organisms such as Streptococcus pneumoniae, Haemophilus influenzae, Klebsiella spp., Staphylococcus aureus, E. coli, and Streptococcus pyogenes

• Skin and Soft Tissue Infections

  • Caused by Staphylococcus aureus (including β-lactamase producing strains) or Streptococcus pyogenes

• Urinary Tract Infections

  • Caused by E. coli or Klebsiella pneumoniae

• Bone and Joint Infections

  • Caused by Staphylococcus aureus

• Sexually Transmitted Infections

  • Gonorrhoea caused by penicillinase- and non-penicillinase-producing strains of Neisseria gonorrhoeae

• Other Infections

  • Early Lyme disease (erythema migrans) caused by Borrelia burgdorferi

Pharmacology

Cefuroxime is a well-established antibacterial agent with broad-spectrum bactericidal activity. It inhibits bacterial cell wall synthesis, leading to cell lysis and death. Cefuroxime demonstrates excellent stability against bacterial β-lactamase enzymes and remains active against many ampicillin- and amoxicillin-resistant strains.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Dosage and Administration

Oral (Tablet or Suspension)

Adolescents and Adults (13 years and older):

• Pharyngitis/Tonsillitis: 250 mg twice daily for 5–10 days

• Acute bacterial sinusitis: 250 mg twice daily for 10 days

• Chronic bronchitis exacerbation: 250–500 mg twice daily for 10 days

• Skin and soft tissue infections: 250–500 mg twice daily for 10 days

• Uncomplicated UTI: 250 mg twice daily for 7–10 days

• Community-acquired pneumonia: 250–500 mg twice daily for 5–10 days

• Uncomplicated gonorrhoea: 1000 mg single dose

• Early Lyme disease: 500 mg twice daily for 20 days

Paediatric Patients (3 months to 12 years):

• Pharyngitis/Tonsillitis: 20 mg/kg/day in two divided doses for 5–10 days

• Acute otitis media: 30 mg/kg/day in two divided doses for 10 days

• Acute bacterial sinusitis: 30 mg/kg/day in two divided doses for 10 days

• Impetigo: 30 mg/kg/day in two divided doses for 10 days

Administration Instructions

Freshly reconstituted suspension is recommended. The reconstituted solution remains stable for up to 24 hours at room temperature or 48 hours when refrigerated at 5°C.

Drug Interactions

No potentially hazardous drug interactions have been reported.

Contraindications

Kilbac is contraindicated in patients with known hypersensitivity to cephalosporin antibiotics.

Side Effects

Cefuroxime is generally well tolerated. Possible side effects include:

• Gastrointestinal disturbances

• Skin rashes
  Prolonged use may lead to overgrowth of non-susceptible organisms such as Candida.

Pregnancy and Lactation

Cefuroxime is classified as US FDA Pregnancy Category B. It should be used during pregnancy only if clearly needed. Cefuroxime is excreted in human milk; therefore, caution is advised during breastfeeding.

Precautions and Warnings

• Use with caution in patients with a history of colitis

• Care is advised when used concurrently with potent diuretics

• Cross-reactivity may occur in penicillin-allergic patients, though it is uncommon at recommended doses

Storage Conditions

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.