Lino 5 mg is an oral antidiabetic medication containing a Dipeptidyl Peptidase-4 (DPP-4) inhibitor. It is prescribed for adults with type 2 diabetes mellitus to improve glycaemic control. Lino 5 mg works by enhancing the body’s natural incretin system, which regulates insulin and glucagon secretion in a glucose-dependent manner, thereby helping maintain stable blood sugar levels.

This medication can be used as monotherapy in patients who cannot achieve adequate glycemic control through diet and exercise alone, particularly when metformin is contraindicated due to renal impairment or intolerance. It can also be used as combination therapy alongside metformin, sulfonylureas, or other antidiabetic agents when single or dual therapies are insufficient to control blood glucose levels.

By improving glucose-dependent insulin secretion and suppressing inappropriate glucagon release, Lino 5 mg helps reduce fasting and postprandial hyperglycemia, supporting long-term metabolic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Lino 5 mg is indicated for:

• Type 2 diabetes mellitus in adults

• Monotherapy for patients inadequately managed with diet and exercise alone, especially when metformin is not suitable

• Combination therapy with metformin, sulfonylureas, or other antidiabetic drugs when glycemic control remains insufficient

Therapeutic Class

Dipeptidyl Peptidase-4 (DPP-4) inhibitor

Pharmacology

Lino 5 mg inhibits DPP-4, the enzyme responsible for breaking down incretin hormones such as GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). By preventing incretin degradation:

• Insulin release from pancreatic beta cells is enhanced in a glucose-dependent manner

• Glucagon release from pancreatic alpha cells is reduced, lowering hepatic glucose production

• Active incretin hormone levels are increased, improving overall glycemic control

This mechanism reduces the risk of hypoglycemia compared to traditional insulin secretagogues while improving postprandial glucose management.

Dosage & Administration

• Adults: Take one tablet once daily, with or without food

• Maintain a consistent schedule if used with metformin

• Dose adjustment for sulfonylurea may be needed to reduce hypoglycemia risk

• No dose modification required in patients with renal impairment

Interactions

• Weak/moderate inhibitor of CYP3A4; clinically significant interactions are unlikely

• No meaningful pharmacokinetic interaction with metformin, glyburide, simvastatin, warfarin, digoxin, or oral contraceptives

Contraindications

• Hypersensitivity to Lino 5 mg or any excipient

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Possible side effects include:

• Hypoglycemia (especially when combined with sulfonylureas or metformin)

• Nasopharyngitis

• Cough

• Pancreatitis (rare)

Precautions & Warnings

• Monitor for signs of hypersensitivity

• Use caution in patients with a history of pancreatitis

• Not recommended for type 1 diabetes or diabetic ketoacidosis

Pregnancy & Lactation

• Pregnancy Category B: Use only if clearly necessary

• Unknown whether Lino 5 mg is excreted in breast milk; avoid breastfeeding unless advised by a physician

Storage

Store in a dry place, protected from heat and light, and keep out of reach of children.

Lino 5 mg provides effective glycemic management in type 2 diabetes mellitus, either as monotherapy for patients intolerant to metformin or in combination therapy to optimize blood sugar control, with a low risk of hypoglycemia and convenient once-daily dosing.