Lomequin 0.3% is a potent ophthalmic antibacterial preparation used to treat a variety of bacterial eye infections, including conjunctivitis, blepharitis, blepharoconjunctivitis, and Staphylococcus aureus–induced corneal ulcers. Its active ingredient belongs to the fluoroquinolone class of antibiotics, making it highly effective against both gram-positive and gram-negative bacteria that are susceptible to this agent.

This eye drop works by inhibiting bacterial DNA replication and repair mechanisms, leading to rapid bacterial death and resolution of eye infections. Lomequin 0.3% is widely used for its safety, efficacy, and low systemic toxicity, making it suitable for adults and children over 1 year of age.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• 4-Quinolone preparations

• Ophthalmic antibacterial drugs

Pharmacology

Lomequin 0.3% is a difluorinated quinolone derivative that targets bacterial DNA gyrase (topoisomerase II). By forming a stable complex with the gyrase enzyme, Lomequin interferes with critical DNA processes including:

• Replication initiation, elongation, and termination

• Transcription and DNA repair

• Recombination, transposition, and supercoiling

This inhibition leads to rapid killing of susceptible bacteria. The drug demonstrates broad-spectrum activity against gram-positive and gram-negative pathogens causing ocular infections. Cross-resistance has only been reported with other quinolones, not with antibiotics from other classes.

Indications

Lomequin 0.3% ophthalmic solution is indicated for:

• Bacterial conjunctivitis

• Blepharitis and blepharoconjunctivitis

• Corneal ulcers caused by Staphylococcus aureus

• Eye infections due to Lomequin-susceptible bacteria

Dosage and Administration

• Adults and children (above 1 year):

  • Instill 1 drop into the lower conjunctival sac 2–3 times daily

  • At the start of treatment, apply 5 drops within 20 minutes or 1 drop every hour for 6–10 hours

• Duration: 7–9 days, or as prescribed

• Lomequin may be used with or without food

Interactions

• Avoid using ophthalmic preparations containing heavy metals, like zinc, within 15 minutes before or after Lomequin

• Bacteriostatic ophthalmic antibiotics should not be used concomitantly

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Lomequin, quinolones, or any excipients

• Prolonged antibiotic use may promote secondary fungal infections or growth of non-susceptible bacteria

Side Effects

• Mild burning or stinging immediately after instillation (4.7% of users)

• Potential for photosensitization, though phototoxicity has not been reported for ophthalmic use

• Rare systemic allergic reactions (from systemic use) may include:

  • Asthma, dyspnea, urticaria, erythema, pruritus, hypersensitivity

Pregnancy & Lactation

• Animal studies show placental transfer and excretion in maternal milk after systemic use

• Human data are limited; use only if benefits outweigh potential risks to the fetus or infant

Precautions

• Avoid prolonged exposure to sunlight or UV light during treatment

• Monitor for signs of allergic reactions

Overdose

• Accidental oral ingestion poses minimal risk due to the small dose in each eye drop (15 mg per 5 ml bottle)

Storage Conditions

• Store at 15–25°C, protected from light

• Keep out of reach of children

Mode of Action

Lomequin 0.3% rapidly kills susceptible bacteria by inhibiting DNA gyrase, blocking essential DNA-related processes, and disrupting bacterial replication and repair. Its broad-spectrum antibacterial activity makes it effective for common ocular infections caused by both gram-positive and gram-negative bacteria.

Drug Classes

• 4-Quinolone preparations

• Ophthalmic antibacterial drugs.