Losardil 100/12.5 Tablet is a combination antihypertensive medication containing Losartan Potassium 100 mg and Hydrochlorothiazide 12.5 mg. This dual-action tablet is specifically formulated for adults with hypertension who require more effective blood pressure control than monotherapy alone.

Losartan, an angiotensin II receptor blocker (ARB), relaxes blood vessels by blocking the effects of angiotensin II, while Hydrochlorothiazide, a thiazide diuretic, reduces fluid retention by increasing urine output. Together, these components provide synergistic blood pressure reduction, improving cardiovascular outcomes and reducing the risk of complications such as stroke, heart attack, and kidney damage.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Mechanism of Action

The combination of Losartan and Hydrochlorothiazide acts through complementary mechanisms:

• Losartan (100 mg):

  • Blocks AT1 receptors, preventing angiotensin II from constricting blood vessels.

  • Promotes vasodilation, reduces systemic vascular resistance, and decreases blood pressure.

  • Offers kidney protection in patients with diabetes or proteinuria.

• Hydrochlorothiazide (12.5 mg):

  • Increases renal excretion of sodium and water, reducing blood volume.

  • Lowers peripheral resistance, contributing to long-term blood pressure reduction.

  • Helps prevent fluid-related complications of hypertension.

The combination ensures more potent and sustained blood pressure control, particularly in patients whose blood pressure is not adequately managed by a single agent.

Indications

Losardil 100/12.5 Tablet is indicated for:

• Essential hypertension: For adults needing enhanced blood pressure control.

• Patients inadequately controlled with monotherapy: Combines the efficacy of Losartan and Hydrochlorothiazide.

• Cardiovascular risk reduction: Lowers the risk of stroke, myocardial infarction, and heart failure.

• Renal protection in diabetics: Helps reduce proteinuria and slow the progression of kidney damage in type 2 diabetes patients.

It is not suitable for patients who are pregnant, breastfeeding, or have severe renal or hepatic impairment, or hypersensitivity to either component.

Dosage and Administration

• The usual adult dose is 1 tablet once daily, taken orally with or without food.

• Swallow the tablet whole with water; do not crush or chew.

• Blood pressure should be monitored regularly to assess response.

• Dosage adjustments may be required in patients with renal or hepatic impairment.

• Continue lifestyle modifications such as diet, exercise, and reduced salt intake for optimal results.

Precautions

• Avoid during pregnancy, as ARBs can cause fetal harm.

• Monitor kidney function, electrolytes, and blood pressure periodically, especially during the initial therapy.

• Inform your doctor about all other medications, particularly potassium supplements, diuretics, or NSAIDs.

• Use caution in patients with low blood pressure, electrolyte imbalances, or dehydration.

• Elderly patients may require closer monitoring due to increased sensitivity to antihypertensive effects.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects include:

• Dizziness or lightheadedness

• Fatigue or headache

• Mild gastrointestinal discomfort such as nausea or abdominal pain

• Increased urination due to diuretic effect

Rare but serious side effects include:

• Hyperkalemia (elevated potassium)

• Hypotension (excessive blood pressure reduction)

• Impaired kidney function

• Severe allergic reactions such as rash, swelling, or difficulty breathing

Seek immediate medical attention if serious side effects occur.

Storage

Store below 30°C in a dry place, protected from sunlight and moisture. Keep out of reach of children.

Losardil 100/12.5 Tablet provides potent and sustained blood pressure control, combining Losartan and Hydrochlorothiazide for optimal cardiovascular and renal protection in hypertensive patients.