Lynparib Tablet 150 mg contains Olaparib, a targeted anticancer medication used in the treatment of certain types of cancer associated with BRCA gene mutations and other DNA repair deficiencies. Olaparib belongs to a class of medicines known as PARP inhibitors (Poly ADP-Ribose Polymerase inhibitors). These drugs work by blocking a key enzyme involved in repairing damaged DNA within cancer cells, ultimately causing the cancer cells to die while limiting damage to healthy cells.

Lynparib Tablet 150 mg is commonly used in the treatment of ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer in patients who have specific genetic mutations or whose disease has responded to prior chemotherapy. By targeting the underlying genetic weakness in cancer cells, Olaparib helps slow tumor growth and may help extend the time before the cancer progresses.

Cancer cells often rely on multiple mechanisms to repair DNA damage. In patients with BRCA1 or BRCA2 gene mutations, one of the major DNA repair pathways is already defective. Olaparib works by inhibiting the PARP enzyme, which blocks an additional repair pathway. This leads to an accumulation of DNA damage in cancer cells, ultimately resulting in cell death. This targeted approach is known as synthetic lethality, making Olaparib particularly effective for cancers with BRCA mutations.

Lynparib Tablet 150 mg is often used as maintenance therapy, meaning it is given after initial treatment such as chemotherapy to help keep the cancer under control and delay recurrence. It may also be prescribed for patients with advanced cancers who have specific genetic markers identified through diagnostic testing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Anticancer agent

• PARP (Poly ADP-Ribose Polymerase) inhibitor

• Targeted therapy

Composition

Each film-coated tablet contains:

• Olaparib 150 mg

The dosage and treatment duration are determined by a healthcare professional based on the patient’s medical condition and response to therapy.

Indications

Lynparib Tablet 150 mg may be prescribed for the treatment of:

• BRCA-mutated ovarian cancer (maintenance or advanced therapy)

• HER2-negative metastatic breast cancer with BRCA mutation

• Metastatic pancreatic cancer with BRCA mutation

• Metastatic castration-resistant prostate cancer with homologous recombination repair gene mutations

Genetic testing is often required before initiating treatment to determine whether the patient will benefit from this targeted therapy.

Mechanism of Action

Olaparib works by inhibiting the PARP enzyme, which plays an important role in repairing damaged DNA in cells. In cancer cells that already have defective DNA repair mechanisms (such as BRCA mutations), blocking PARP prevents the cells from repairing DNA damage. This leads to accumulation of DNA errors, causing cancer cells to stop growing and eventually die.

Dosage and Administration

• The typical dose is determined by the prescribing oncologist.

• Tablets are usually taken twice daily, with or without food.

• Swallow the tablets whole with water and do not crush or chew them.

• Treatment should continue for as long as recommended by the healthcare provider.

Patients should follow their doctor’s instructions carefully and attend regular monitoring appointments.

Possible Side Effects

Common side effects may include:

• Fatigue or weakness

• Nausea and vomiting

• Decreased appetite

• Anemia (low red blood cell count)

• Diarrhea or abdominal discomfort

• Headache

More serious side effects may occur in rare cases, including blood disorders or lung problems. Patients should report any unusual symptoms to their healthcare provider immediately.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under the supervision of a qualified oncologist.

• Blood tests may be required regularly during treatment.

• Not recommended during pregnancy or breastfeeding.

• Patients should inform their doctor about all medications they are taking to avoid potential drug interactions.

Storage

Store below 30°C in a dry place, protected from moisture and direct sunlight. Keep the medication out of reach of children.