Meglu ER Tablet 500 mg contains Metformin Hydrochloride, a long-acting (extended-release) oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Metformin belongs to the biguanide class of medications and works primarily by reducing hepatic glucose production (gluconeogenesis) and improving insulin sensitivity in peripheral tissues, including skeletal muscle and fat.

The extended-release (ER) formulation allows for gradual release of metformin over 12–24 hours, maintaining stable blood glucose levels throughout the day. This formulation reduces the risk of gastrointestinal side effects commonly associated with immediate-release metformin, such as nausea, diarrhea, and abdominal discomfort. Meglu ER Tablet 500 mg is designed for once-daily or twice-daily dosing, enhancing convenience and adherence for patients requiring long-term glycemic control.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Meglu ER Tablet 500 mg is indicated for:

• Type 2 diabetes mellitus in adults and adolescents (≥10 years)

• Monotherapy in patients not adequately controlled with diet and exercise alone

• Combination therapy with other oral antidiabetic agents or insulin when monotherapy is insufficient

• Management of insulin resistance and metabolic syndrome

• Prevention of type 2 diabetes in high-risk individuals, under medical supervision

Meglu ER helps maintain fasting and postprandial blood sugar levels, reduce the risk of diabetes-related complications, and support weight management and metabolic health.

Dosage and Administration

Recommended dosage:

• Adults: Typically 500 mg once daily with the main meal, adjustable based on glycemic response

• Maximum daily dose: 2,000–2,500 mg, divided into 1–2 ER tablets depending on clinical response

• Pediatric patients: Dose should be individualized based on age, weight, and physician guidance

Administration guidelines:

• Swallow tablets whole; do not crush, chew, or break

• Take with the main meal to improve absorption and reduce gastrointestinal discomfort

• Maintain a consistent daily schedule for optimal blood glucose control

• Regular monitoring of blood glucose and HbA1c levels is recommended to assess effectiveness

Precautions and Warnings

• Lactic acidosis: Rare but serious; risk increases in patients with renal impairment, liver disease, severe infection, dehydration, or excessive alcohol consumption

• Renal function: Monitor regularly; contraindicated in severe renal disease

• Hepatic impairment: Use cautiously in patients with liver dysfunction

• Contrast imaging: Temporarily discontinue before iodinated contrast studies to reduce renal risk

• Pregnancy and breastfeeding: Generally safe under medical supervision; consult a physician

• Drug interactions: Certain medications, including diuretics and corticosteroids, may affect blood glucose control

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Meglu ER Tablet 500 mg is generally well tolerated. Common side effects include:

• Gastrointestinal disturbances: nausea, diarrhea, abdominal discomfort, or bloating

• Mild metallic taste in the mouth

• Rarely, long-term use may lead to vitamin B12 deficiency

Severe side effects such as lactic acidosis are extremely rare but require immediate medical attention. Most adverse effects are mild and transient, often resolving with continued therapy.

Storage

Store in a cool, dry place below 25°C, away from light and moisture. Keep tablets in their original packaging and out of reach of children.

Meglu ER Tablet 500 mg (Metformin Hydrochloride) is an effective, long-acting antidiabetic therapy that provides steady blood glucose control, reduced gastrointestinal discomfort, and convenient dosing, making it ideal for patients with type 2 diabetes seeking improved adherence and metabolic health.