Naligram Tablet 500 mg contains Nalidixic Acid, a synthetic quinolone antibiotic used primarily to treat urinary tract infections (UTIs) caused by susceptible bacteria. It is effective against Gram-negative organisms, particularly Escherichia coli and Proteus species, which are common causative agents of UTIs. Naligram works by inhibiting bacterial DNA replication, thereby stopping bacterial growth and promoting elimination of the infection.

Nalidixic Acid belongs to the first generation of quinolone antibiotics. It is bactericidal, meaning it actively kills bacteria rather than merely inhibiting their growth. Its activity is mainly concentrated in the urinary tract, making it a preferred choice for uncomplicated urinary tract infections. The drug is absorbed rapidly after oral administration and is primarily excreted unchanged in the urine, ensuring high concentrations at the site of infection.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Naligram Tablet 500 mg is indicated for the treatment of:

• Acute uncomplicated urinary tract infections

• Cystitis and pyelonephritis caused by susceptible Gram-negative bacteria

• Prophylaxis of recurrent urinary tract infections in selected cases as advised by a physician

It should be used only for infections confirmed or strongly suspected to be caused by susceptible organisms.

Dosage and Administration

The usual adult dose of Naligram Tablet 500 mg is one tablet every 6–12 hours, depending on the severity of the infection and medical guidance. The tablet should be swallowed whole with a sufficient amount of water. It can be taken with or without food.

Treatment duration is typically 7–10 days for acute infections, but the exact duration should be determined by a healthcare professional based on the type of infection and patient response. Completing the full course is essential to prevent recurrence and reduce the risk of antibiotic resistance.

Precautions and Warnings

• Not recommended in patients with hypersensitivity to nalidixic acid or other quinolone antibiotics.

• Use with caution in patients with a history of renal impairment, as dose adjustment may be necessary.

• Avoid excessive sunlight or UV exposure, as photosensitivity reactions may occur.

• Drink plenty of fluids to prevent crystalluria (crystals in urine) and support kidney function.

• Inform the physician about all medications being taken to avoid potential drug interactions.

• Not recommended for use in children under one year or during pregnancy and breastfeeding unless specifically prescribed.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Side Effects

Naligram Tablet 500 mg is generally well tolerated. Common side effects may include:

• Nausea and vomiting

• Diarrhea

• Dizziness or headache

• Abdominal discomfort

Rare but serious adverse effects may include hypersensitivity reactions, crystalluria, hematuria, or neurological effects such as seizures in susceptible individuals. Patients should seek immediate medical attention if severe reactions occur.

Storage

Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.

Naligram Tablet 500 mg provides effective therapy for urinary tract infections caused by susceptible bacteria, ensuring rapid symptom relief and supporting a complete recovery when used responsibly under medical supervision.