Naspro Plus Tablet 375 mg+20 mg is a combination medication containing Naproxen Sodium, a non-steroidal anti-inflammatory drug (NSAID), and Esomeprazole Magnesium, a proton pump inhibitor (PPI). This dual-action formulation is designed to provide effective pain relief while protecting the stomach from acid-related side effects commonly associated with NSAIDs. It is especially useful for patients who require long-term anti-inflammatory treatment but are at risk of gastrointestinal irritation or ulcers.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Naproxen Sodium 375 mg
• Esomeprazole Magnesium 20 mg

Mechanism of Action

Naproxen Sodium works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the production of prostaglandins responsible for pain, inflammation, and fever.

Esomeprazole Magnesium reduces the production of stomach acid by blocking the proton pump (H+/K+ ATPase) in gastric parietal cells. This helps protect the stomach lining from irritation and prevents ulcer formation caused by NSAID use.

Together, these components provide effective pain relief with enhanced gastrointestinal safety.

Indications

Naspro Plus Tablet is indicated for the treatment of:

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Chronic musculoskeletal pain
• Back pain and joint pain
• Conditions requiring long-term NSAID therapy with gastric protection

Dosage and Administration

• Take the medication exactly as prescribed by a registered physician.
• It is usually taken before meals for optimal effectiveness of Esomeprazole.
• Swallow the tablet whole with water; do not crush or chew.
• Do not exceed the recommended dose or duration.

Benefits

• Provides effective and sustained pain relief
• Reduces inflammation and joint stiffness
• Protects against NSAID-induced gastric irritation and ulcers
• Suitable for long-term use under medical supervision
• Improves patient compliance with combination therapy

Side Effects

Common side effects may include:

• Nausea
• Abdominal discomfort
• Headache
• Diarrhea or constipation
• Flatulence

Serious but rare side effects:

• Gastrointestinal bleeding
• Severe allergic reactions
• Kidney or liver impairment
• Vitamin B12 deficiency with prolonged use

Seek immediate medical attention if severe symptoms occur.

Precautions and Warnings

• Use cautiously in patients with a history of gastrointestinal ulcers or bleeding.
• Long-term use should be monitored due to potential risks such as kidney issues or nutrient deficiencies.
• Patients with liver, kidney, or heart conditions should consult a doctor before use.
• Avoid alcohol as it may increase gastrointestinal risks.
• Not recommended during late pregnancy unless advised by a physician.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Naspro Plus may interact with:

• Other NSAIDs or aspirin
• Anticoagulants (e.g., warfarin)
• Corticosteroids
• Clopidogrel and other antiplatelet drugs
• Certain antifungals and antibiotics
• Drugs affected by stomach pH (due to esomeprazole)

Always inform your healthcare provider about all medicines you are taking.

Storage

• Store below 30°C in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children.