Niloren Capsule 200 mg contains Nilotinib, a tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukemia (CML). Nilotinib works by selectively inhibiting the BCR-ABL protein, which is responsible for abnormal growth of leukemia cells. Niloren is prescribed for patients with Philadelphia chromosome-positive CML, helping to control disease progression, achieve remission, and improve long-term survival.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Niloren Capsule 200 mg is indicated for:

• Philadelphia chromosome-positive chronic myeloid leukemia (CML)

• Adult patients newly diagnosed with chronic phase CML

• Patients resistant or intolerant to prior therapy with imatinib

• Management of disease progression prevention in CML

Mechanism of Action

Nilotinib works by:

• Inhibiting the BCR-ABL tyrosine kinase, which drives leukemia cell proliferation

• Blocking signaling pathways responsible for uncontrolled cell division

• Reducing the number of leukemia cells in the blood and bone marrow

• Providing targeted therapy with higher specificity and efficacy compared to conventional chemotherapy

Dosage and Administration

• Recommended dose: 200 mg orally twice daily or as prescribed by a hematologist

• Take capsules on an empty stomach, at least 1 hour before or 2 hours after meals

• Swallow capsules whole; do not crush, chew, or open

• Regular blood counts, liver function, and ECG monitoring are required during therapy

Benefits

• Effective targeted therapy for CML

• Helps achieve hematologic and cytogenetic remission

• Reduces disease progression risk

• Well-tolerated with manageable side effects under supervision

• Oral therapy allows outpatient treatment and improved quality of life

Precautions

• Inform your doctor if you have:

  • Heart problems, including arrhythmias or prolonged QT interval

  • Liver or kidney impairment

  • History of pancreatitis

• Avoid grapefruit or grapefruit juice, which can interfere with drug metabolism

• Strict adherence to dosage and monitoring schedule is essential

Side Effects

Common side effects may include:

• Fatigue

• Nausea or vomiting

• Headache

• Rash or itching

Serious side effects:

• QT interval prolongation or cardiac arrhythmias

• Liver enzyme elevation

• Pancreatitis

• Myelosuppression (low blood counts)

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

• Store at room temperature (20–25°C)

• Keep in a dry place, away from light

• Keep out of reach of children

Conclusion

Niloren Capsule 200 mg is a targeted, highly effective therapy for Philadelphia chromosome-positive CML. By inhibiting BCR-ABL tyrosine kinase, it helps control leukemia progression, supports remission, and improves long-term outcomes when used under careful medical supervision.