Nopain Extra Tablet is a combination medication containing Diclofenac Sodium 50 mg and Misoprostol 200 mcg. This formulation is designed to provide effective relief from pain and inflammation while reducing the risk of gastric ulcers associated with long-term NSAID use.

Diclofenac Sodium is a non-steroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX) enzymes, thereby decreasing the production of prostaglandins responsible for pain, swelling, and inflammation. Misoprostol, a synthetic prostaglandin E1 analogue, helps protect the stomach lining by increasing mucus and bicarbonate secretion and enhancing mucosal blood flow. This protective action reduces the risk of gastric and duodenal ulcers commonly linked to NSAID therapy.

Nopain Extra Tablet is particularly beneficial for patients requiring long-term anti-inflammatory treatment but who are at risk of gastrointestinal complications.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Nopain Extra Tablet is indicated for:

• Osteoarthritis

• Rheumatoid arthritis

• Ankylosing spondylitis

• Chronic inflammatory joint disorders

• Patients at high risk of NSAID-induced gastric ulcers

• Long-term management of pain and inflammation requiring gastric protection

This combination is especially useful in patients with a history of peptic ulcer disease or those requiring continuous NSAID therapy.

Key Benefits

• Effective pain and inflammation control: Diclofenac provides strong analgesic and anti-inflammatory action.

• Gastric protection: Misoprostol helps prevent NSAID-induced gastric and duodenal ulcers.

• Improved safety profile: Reduces gastrointestinal complications compared to diclofenac alone.

• Convenient combination therapy: Two medications in one tablet enhance compliance.

• Suitable for long-term use: Particularly in chronic arthritic conditions under medical supervision.

Nopain Extra Tablet offers balanced treatment by combining symptom relief with gastrointestinal protection.

Dosage and Administration

• Usually one tablet taken 2–3 times daily, as prescribed by a physician.

• Take with food and a full glass of water to minimize stomach discomfort.

• Swallow the tablet whole; do not crush or chew.

• Follow the prescribed dosage strictly.

• The lowest effective dose should be used for the shortest necessary duration.

Precautions

• Contraindicated in pregnancy, as misoprostol may cause uterine contractions and miscarriage. Women of childbearing potential should use effective contraception during treatment.

• Use cautiously in patients with liver, kidney, or cardiovascular disease.

• Avoid concurrent use with other NSAIDs.

• Inform your doctor about any history of gastrointestinal bleeding, ulcer disease, or inflammatory bowel disease.

• Monitor for signs of stomach pain, bleeding, or allergic reactions.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Abdominal pain or diarrhea (more common due to misoprostol)

• Nausea or indigestion

• Headache or dizziness

• Flatulence

Rare but serious effects include gastrointestinal bleeding, severe allergic reactions, liver dysfunction, or cardiovascular events. Immediate medical attention is necessary if severe abdominal pain, black stools, chest pain, or difficulty breathing occurs.

Storage Instructions

• Store below 25°C in a cool, dry place.

• Protect from moisture and direct sunlight.

• Keep out of reach of children.

• Do not use after the expiration date printed on the packaging.

Nopain Extra Tablet (Diclofenac Sodium + Misoprostol) provides effective anti-inflammatory relief with added gastric protection, making it a valuable option for patients requiring long-term NSAID therapy under medical supervision.