Orbas Plus Tablet 20 mg+12.5 mg is a combination antihypertensive medication containing Olmesartan Medoxomil 20 mg and Hydrochlorothiazide 12.5 mg, designed for effective management of high blood pressure (hypertension) in adults. Hypertension is a common chronic condition that increases the risk of stroke, heart attack, and kidney disease. By combining two complementary mechanisms, Orbas Plus offers enhanced blood pressure control and reduces cardiovascular risk in patients requiring combination therapy.

• Olmesartan Medoxomil is an angiotensin II receptor blocker (ARB) that prevents blood vessel constriction and reduces sodium and water retention.

• Hydrochlorothiazide is a thiazide diuretic that promotes excretion of excess sodium and water through urine, lowering blood volume and blood pressure.

The combination of these agents provides synergistic antihypertensive effects, making it ideal for patients whose blood pressure is not adequately controlled with monotherapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Effectively reduces systolic and diastolic blood pressure

• Dual-action therapy ensures better blood pressure control than either component alone

• Reduces the risk of cardiovascular complications associated with hypertension

• Once-daily dosing improves patient compliance and convenience

• Protects heart, kidneys, and blood vessels from hypertensive damage

• Suitable for long-term management of essential hypertension

Mechanism of Action

Orbas Plus Tablet works through the combined actions of Olmesartan and Hydrochlorothiazide:

1. Olmesartan Medoxomil 20 mg:

   • Blocks angiotensin II type 1 (AT1) receptors, preventing vasoconstriction.

   • Reduces aldosterone-mediated sodium and water retention.

   • Promotes vasodilation, decreasing peripheral resistance and cardiac workload.

2. Hydrochlorothiazide 12.5 mg:

   • Increases urinary excretion of sodium and water, lowering blood volume.

   • Enhances reduction in blood pressure, especially in salt-sensitive patients.

3. Synergistic Effect:

   • The combination targets two distinct pathways of blood pressure regulation, providing more effective and sustained control compared to monotherapy.

Indications

Orbas Plus Tablet 20 mg+12.5 mg is indicated for:

• Adults with essential hypertension requiring combination therapy

• Patients not adequately controlled with Olmesartan or Hydrochlorothiazide alone

• Long-term prevention of stroke, heart attack, and kidney damage related to hypertension

• Maintenance of stable blood pressure in patients at cardiovascular risk

Dosage and Administration

• Recommended dose: One tablet once daily, orally, or as prescribed by a healthcare professional.

• Can be taken with or without food, preferably at the same time each day.

• Swallow the tablet whole; do not crush or chew.

• Regular monitoring of blood pressure, kidney function, and electrolytes is recommended.

Precautions and Warnings

• Not recommended in pregnancy, breastfeeding, severe hypotension, or known hypersensitivity to ARBs or thiazides.

• Use caution in patients with renal or hepatic impairment.

• Inform your physician about all other medications to avoid interactions.

• Avoid abrupt discontinuation to prevent rebound hypertension.

• Monitor kidney function, electrolytes, and uric acid levels during therapy.

Possible Side Effects

Common side effects may include:

• Dizziness or lightheadedness

• Headache

• Fatigue

• Increased urination

• Mild gastrointestinal disturbances (nausea, abdominal discomfort)

Rare but serious side effects may include severe hypotension, kidney dysfunction, electrolyte imbalance, or allergic reactions. Seek medical attention if severe symptoms occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage

Store below 30°C in a dry, cool place, protected from light and moisture. Keep out of reach of children.

Orbas Plus Tablet 20 mg+12.5 mg offers effective dual-action blood pressure control, combining Olmesartan and Hydrochlorothiazide to reduce cardiovascular risk, protect vital organs, and provide long-term management of hypertension.