Palotic Tablet 0.5 mg contains Palonosetron, a second-generation selective serotonin (5-HT3) receptor antagonist used for the prevention of nausea and vomiting. It is primarily indicated for chemotherapy-induced nausea and vomiting (CINV) and is known for its long duration of action, providing sustained antiemetic protection with convenient oral administration.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Palonosetron 0.5 mg

Indications

Palotic Tablet is indicated for:

• Prevention of chemotherapy-induced nausea and vomiting (acute and delayed phases)
• Management of nausea and vomiting associated with cancer therapy
• Supportive care in patients receiving moderately to highly emetogenic chemotherapy
• Prevention of treatment-related emesis where long-acting antiemetic therapy is required

Mechanism of Action

Palonosetron works by selectively blocking serotonin (5-HT3) receptors in the gastrointestinal tract and central nervous system. This prevents serotonin from activating the vomiting reflex pathway, thereby reducing nausea and vomiting. Its strong receptor binding affinity and long half-life ensure prolonged antiemetic activity.

Dosage and Administration

• Usually taken as a single oral dose before chemotherapy, or as directed by a physician.
• Should be swallowed whole with water.
• Dosage may vary depending on chemotherapy regimen and patient condition.
• Use strictly under medical supervision.

Benefits

• Effective prevention of chemotherapy-induced nausea and vomiting
• Long-lasting protection with single-dose convenience
• Improves patient comfort during cancer treatment
• Reduces need for repeated antiemetic dosing
• Well-established safety and efficacy profile

Side Effects

Palotic Tablet is generally well tolerated. Some possible side effects include:

• Headache
• Constipation
• Dizziness
• Fatigue
• Abdominal discomfort

Serious side effects are rare but should be reported immediately to a healthcare provider.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions and Warnings

• Use only under medical supervision.
• Caution in patients with cardiac conditions, especially QT prolongation.
• Inform your doctor about all medications being taken to avoid interactions.
• Use with caution in hepatic impairment.
• Not intended for self-medication.

Storage

• Store below 25°C
• Protect from moisture and light
• Keep out of reach of children.