Pantobex Injection 40 mg/vial contains Pantoprazole Sodium, a proton pump inhibitor (PPI) that effectively suppresses gastric acid secretion. It is formulated for intravenous administration and is especially useful in patients who are unable to take oral medication or in acute clinical settings where rapid acid suppression is required.

Pantoprazole works by selectively and irreversibly inhibiting the H⁺/K⁺-ATPase enzyme system (proton pump) in the gastric parietal cells. By blocking the final step of acid production, Pantobex Injection provides potent and sustained reduction of both basal and stimulated gastric acid secretion, regardless of the stimulus.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Pantobex Injection 40 mg/vial is indicated in conditions where inhibition of gastric acid secretion is therapeutically beneficial, including:

• Gastroesophageal reflux disease (GERD) and erosive esophagitis

• Gastric and duodenal ulcer disorders

• Prevention and treatment of NSAID-induced gastric ulcers

• Zollinger–Ellison syndrome and other pathological hypersecretory conditions

• Helicobacter pylori eradication (as part of combination therapy with appropriate antibiotics)

• Stress-related mucosal damage and upper gastrointestinal bleeding in critically ill patients

Therapeutic Class

• Proton Pump Inhibitor (PPI)

Pharmacology

Pantoprazole Sodium is a substituted benzimidazole that suppresses the final step of gastric acid production by covalent binding to the proton pump. Following intravenous administration, pantoprazole is rapidly distributed to the gastric parietal cells, where it is converted to its active sulfenamide form in the acidic environment. This results in a dose-dependent and long-lasting reduction of gastric acid secretion.

Acid suppression occurs within a short time after administration and is maintained for up to 24 hours, making once-daily dosing sufficient in most cases.

Dosage and Administration

The usual recommended dose is 40 mg once daily, administered intravenously as a slow injection or infusion, depending on clinical requirements. Dosage may be adjusted based on the severity of the condition and physician judgment. Transition to oral pantoprazole is recommended once the patient can tolerate oral therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Use in Special Populations

• Hepatic impairment: Dose adjustment may be required

• Renal impairment: No dose adjustment is generally necessary

• Elderly: Can be used at standard doses with monitoring

Adverse Effects

Pantobex Injection is generally well tolerated. Possible side effects include:

• Headache

• Diarrhea or constipation

• Nausea and vomiting

• Abdominal pain

• Injection site reactions

Serious adverse reactions are rare when used at recommended doses.

Storage

Store in a cool, dry place below 25°C. Protect from light. Keep out of reach of children.