Periset Oral Solution 4 mg/5 ml contains Ondansetron, a potent 5-HT3 receptor antagonist used to prevent and treat nausea and vomiting caused by chemotherapy, radiotherapy, or surgical procedures. Ondansetron works by blocking serotonin (5-HT3) receptors in the gastrointestinal tract and central nervous system, which are primarily responsible for triggering the vomiting reflex.

This oral solution formulation provides a convenient and easy-to-administer option for patients who have difficulty swallowing tablets, such as children, the elderly, or individuals undergoing medical treatments that induce nausea. The solution ensures rapid absorption, offering effective control over both acute and delayed episodes of nausea and vomiting.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Key Benefits

• Prevents chemotherapy-induced nausea and vomiting (CINV)

• Reduces radiotherapy-induced nausea and vomiting (RINV)

• Controls postoperative nausea and vomiting (PONV)

• Convenient oral solution for easy administration, especially in children and patients with swallowing difficulties

• Rapid onset of action for effective symptom control

• Improves patient comfort, treatment adherence, and quality of life

Mechanism of Action

Ondansetron, the active ingredient in Periset Oral Solution, acts as a selective 5-HT3 receptor antagonist:

1. Blocking Serotonin Receptors:

   • Chemotherapy, radiotherapy, or surgical stress can trigger the release of serotonin from enterochromaffin cells in the gut.

   • Serotonin binds to 5-HT3 receptors on vagal nerve endings, activating the vomiting center in the brain.

   • Ondansetron blocks these receptors, preventing nausea and vomiting signals from being transmitted.

2. Peripheral and Central Action:

   • Acts on 5-HT3 receptors in the gastrointestinal tract and the central nervous system, providing comprehensive antiemetic protection.

3. Rapid Absorption and Effect:

   • Oral administration ensures that Ondansetron quickly enters the bloodstream, providing fast and reliable relief from nausea and vomiting.

Indications

Periset Oral Solution 4 mg/5 ml is indicated for:

• Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV)

• Prevention of radiotherapy-induced nausea and vomiting (RINV)

• Prevention and treatment of postoperative nausea and vomiting (PONV)

• Suitable for pediatric and adult patients requiring oral administration

Dosage and Administration

• Adults: 8 mg orally, 30 minutes before chemotherapy, followed by 8 mg every 12 hours for 1–2 days after treatment, or as directed by a physician.

• Children: Dose is usually weight-based (approximately 0.15 mg/kg per dose, up to a maximum of 8 mg), administered 30 minutes before chemotherapy.

• Shake the bottle well before use to ensure uniform suspension.

• Can be taken with or without food.

• Always follow the prescribed dosing schedule to prevent breakthrough nausea.

Precautions and Warnings

• Use with caution in patients with liver impairment or cardiac arrhythmias.

• Avoid use in patients with known hypersensitivity to Ondansetron or other 5-HT3 antagonists.

• May interact with other drugs that prolong the QT interval; ECG monitoring may be required in at-risk patients.

• Pregnant and breastfeeding women should use Ondansetron only under medical supervision.

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Periset Oral Solution is generally well-tolerated. Common side effects include:

• Headache

• Constipation or diarrhea

• Dizziness or fatigue

• Rarely, allergic reactions, arrhythmias, or severe hypersensitivity

Seek medical attention if severe reactions such as rash, swelling, or difficulty breathing occur.

Storage

Store below 30°C in a cool, dry place, protected from light. Keep out of reach of children.

Periset Oral Solution 4 mg/5 ml provides effective, fast-acting relief from nausea and vomiting, making it an essential option for patients undergoing chemotherapy, radiotherapy, or surgery.