Pime-4 Injection 500 mg/vial contains Cefepime Hydrochloride, a fourth-generation cephalosporin antibiotic with broad-spectrum activity. It is used to treat serious bacterial infections caused by susceptible Gram-positive and Gram-negative bacteria. Cefepime works by interfering with bacterial cell wall synthesis, leading to bacterial death. Pime-4 is commonly administered in hospital settings for severe infections, including respiratory tract infections, urinary tract infections, skin infections, and sepsis.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each vial contains:

• Cefepime Hydrochloride 500 mg (as sterile lyophilized powder for injection)

Mechanism of Action

Cefepime, a beta-lactam antibiotic, works by:

• Inhibiting bacterial cell wall synthesis
• Binding to penicillin-binding proteins (PBPs)
• Causing cell lysis and death in susceptible bacteria

It exhibits rapid bactericidal activity against a wide range of Gram-positive and Gram-negative organisms, including Pseudomonas aeruginosa and Enterobacteriaceae.

Indications

Pime-4 Injection is indicated for:

• Severe respiratory tract infections (pneumonia, bronchitis)
• Urinary tract infections (complicated and uncomplicated)
• Skin and soft tissue infections
• Intra-abdominal infections
• Septicemia and bacteremia
• Febrile neutropenia in immunocompromised patients

Dosage and Administration

• Administered intravenously or intramuscularly under medical supervision.
• Dosage depends on the severity of infection, renal function, and patient age.
• Reconstitution should be done with appropriate diluents as per guidelines.
• Typically administered every 12–24 hours; severe infections may require higher doses or more frequent administration.
• Monitor patient response and adjust dosing accordingly.

Benefits

• Broad-spectrum antibacterial coverage
• Effective against multidrug-resistant bacteria
• Rapid bactericidal action
• Suitable for severe and complicated infections
• Versatile dosing for adult and pediatric patients

Side Effects

Common side effects may include:

• Pain or inflammation at the injection site
• Nausea or vomiting
• Diarrhea
• Headache

Serious side effects, although rare, may include:

• Hypersensitivity reactions (rash, anaphylaxis)
• Seizures in patients with severe renal impairment
• Clostridium difficile-associated diarrhea

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Precautions

• Assess for history of penicillin or cephalosporin allergy before use.
• Adjust dosage in patients with renal impairment.
• Monitor for superinfections during prolonged therapy.
• Use with caution in neonates and elderly patients.
• Ensure proper hydration to reduce risk of renal complications.

Storage

• Store lyophilized powder below 25°C
• Protect from light and moisture
• Reconstituted solution should be used immediately or stored as per guidelines
• Keep out of reach of children.