Ribox 60 mg is a potent, orally active non-steroidal anti-inflammatory drug (NSAID) that provides relief from pain, inflammation, and fever. It is a selective cyclooxygenase-2 (COX-2) inhibitor, which makes it effective in treating inflammatory conditions while minimizing gastrointestinal side effects commonly associated with non-selective NSAIDs. Ribox 60 mg is suitable for the management of arthritis, acute pain, and post-operative discomfort, offering targeted relief with a favorable safety profile when used as recommended.

This medication is primarily used for symptomatic management of musculoskeletal disorders, including osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and acute gouty arthritis. It is also effective for short-term moderate pain relief after dental surgery. By selectively inhibiting COX-2, Ribox 60 mg reduces prostaglandin synthesis involved in pain, swelling, and inflammation while sparing COX-1, which protects the stomach lining and supports normal platelet function.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Therapeutic Class

• Non-steroidal Anti-inflammatory Drugs (NSAIDs)

Indications

• Osteoarthritis (OA)

• Rheumatoid arthritis (RA)

• Ankylosing spondylitis

• Acute gouty arthritis

• Moderate pain associated with dental surgery (short-term)

Pharmacology

Ribox 60 mg exerts anti-inflammatory, analgesic, and antipyretic effects by selectively inhibiting COX-2 enzymes. Unlike non-selective NSAIDs, it spares COX-1, reducing the risk of gastrointestinal toxicity and platelet aggregation interference. The drug works by decreasing the production of prostanoids that mediate pain, swelling, and fever, providing effective symptom control in inflammatory conditions.

Mode of Action

• Selective COX-2 inhibition: Reduces prostaglandin-mediated pain and inflammation

• Spare COX-1 activity: Minimizes gastrointestinal side effects and preserves platelet function

• Analgesic and anti-inflammatory: Rapidly alleviates pain, swelling, and stiffness associated with arthritis and musculoskeletal disorders

Dosage and Administration

Adults and adolescents (over 16 years):

• Osteoarthritis: 30–60 mg once daily, adjusted based on symptom relief

• Rheumatoid arthritis / Ankylosing spondylitis: 90 mg once daily

• Acute gouty arthritis: 120 mg once daily for up to 8 days

• Post-dental surgery pain: 90 mg once daily, limited to 3 days

General Guidelines:

• Take with or without food

• Use the lowest effective dose for the shortest duration possible to reduce cardiovascular and gastrointestinal risks

• Reassess patient response periodically, especially in chronic conditions

Drug Interactions

• Oral anticoagulants (warfarin): May increase prothrombin time

• Diuretics, ACE inhibitors, ARBs: Reduced antihypertensive effect possible

• Lithium: Increased plasma levels

• Ciclosporin and tacrolimus: Increased nephrotoxicity risk

• Aspirin (low-dose): Can be co-administered safely

  রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Contraindications

• Hypersensitivity to Ribox or any NSAID

• Active peptic ulcer or GI bleeding

• Severe hepatic or renal impairment

• Children and adolescents under 16

• Pregnancy and lactation

• Inflammatory bowel disease, congestive heart failure (NYHA II–IV), uncontrolled hypertension, ischemic heart disease, cerebrovascular disease

Side Effects

• Common: Palpitations, fatigue, influenza-like symptoms, ecchymosis

• Less common: Dry mouth, taste changes, mouth ulcers, atrial fibrillation, transient ischemic attack, chest pain, flushing, cough, dyspnea

• Rare: Confusion, hallucinations, electrolyte disturbances, myalgia, arthralgia

Precautions & Warnings

• Caution in patients at risk of gastrointestinal, cardiovascular, or renal complications

• Monitor liver and kidney function during prolonged therapy

• Discontinue if rash, hypersensitivity, or abnormal liver function develops

• May mask fever or inflammation signs

• Avoid use in patients with high cardiovascular risk unless benefits outweigh risks

Pregnancy & Lactation

• Avoid in late pregnancy due to risk of premature ductus arteriosus closure

• Use during breastfeeding is not recommended

Overdose

• Supportive care: Gastric lavage, electrolyte correction, and clinical monitoring

• No specific antidote is available

Storage Conditions

• Store below 30°C in a dry place, protected from light and moisture

• Keep out of reach of children.