Rofumil Tablet 500 mcg contains Roflumilast, an oral medication used in the management of chronic obstructive pulmonary disease (COPD), particularly in patients with severe airflow limitation and a history of frequent exacerbations. Roflumilast belongs to the class of phosphodiesterase-4 (PDE4) inhibitors, which work by reducing inflammation in the lungs.

Rofumilast is prescribed to help prevent exacerbations, improve lung function, and enhance the quality of life in patients with chronic respiratory conditions. It is not a rescue medication for acute breathing difficulties but is used as a long-term maintenance therapy.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Roflumilast 500 mcg per tablet

Mechanism of Action

Roflumilast selectively inhibits phosphodiesterase-4 (PDE4), an enzyme involved in the inflammatory process of the lungs. By inhibiting PDE4, Rofumilast:

• Increases intracellular cyclic AMP (cAMP)

• Reduces the release of pro-inflammatory mediators such as cytokines and chemokines

• Decreases airway inflammation and remodeling

• Reduces the frequency of COPD exacerbations

This targeted anti-inflammatory action helps stabilize lung function and reduces the risk of hospitalization due to severe flare-ups.

Indications

Rofumil Tablet 500 mcg is indicated for:

• Severe COPD with chronic bronchitis

• Patients with a history of frequent COPD exacerbations

• As an adjunct to bronchodilator therapy for long-term maintenance

It is particularly useful in patients who continue to experience exacerbations despite using standard inhaled therapies.

Dosage and Administration

The recommended dose is 500 mcg orally once daily. The tablet should be swallowed whole with water and can be taken with or without food.

Rofumilast is intended for chronic use, and patients should continue therapy even if symptoms improve. It is not suitable for acute relief of breathlessness. Regular follow-up with a healthcare provider is recommended to monitor response and tolerability.

Benefits

• Reduces airway inflammation in COPD patients

• Decreases the frequency and severity of COPD exacerbations

• Supports improved lung function and respiratory health

• Enhances quality of life and daily activity tolerance

• Convenient once-daily oral dosing

Precautions

Rofumilast should be used with caution in patients with liver impairment or psychiatric disorders, including depression. Weight loss may occur in some patients, and nutritional status should be monitored.

It is not recommended for use in children or for the treatment of acute COPD attacks. Patients should inform their healthcare provider about all medications to prevent drug interactions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Possible Side Effects

Common side effects may include:

• Diarrhea

• Nausea and vomiting

• Headache

• Weight loss

• Insomnia

Rare but serious side effects may include depression, mood changes, or suicidal thoughts. Patients should report any severe psychological symptoms immediately.

Storage

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Rofumil Tablet 500 mcg offers an effective, long-term anti-inflammatory option for patients with severe COPD, helping reduce exacerbations and improve overall respiratory health.