Salflu Inhalation Capsule 50 mcg+500 mcg is a high-strength combination therapy designed for the long-term management of severe asthma and chronic obstructive pulmonary disease (COPD). It contains Salmeterol 50 mcg, a long-acting beta-2 adrenergic agonist (LABA), and Fluticasone Propionate 500 mcg, an inhaled corticosteroid (ICS). The combination provides dual therapeutic action: Salmeterol ensures prolonged bronchodilation, while Fluticasone Propionate suppresses airway inflammation, offering enhanced symptom control and prevention of exacerbations.

This formulation is intended for patients whose symptoms are not adequately controlled with lower-dose ICS/LABA therapy or those who require intensive maintenance therapy to improve lung function, reduce hospitalizations, and enhance quality of life. By addressing both airway obstruction and inflammation, Salflu 50/500 mcg provides a comprehensive approach to severe respiratory conditions.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

Each inhalation capsule contains:

• Salmeterol 50 mcg

• Fluticasone Propionate 500 mcg

• Inactive ingredients to stabilize the powder and ensure consistent delivery via a dry powder inhaler (DPI)

Indications

Salflu Inhalation Capsule 50 mcg+500 mcg is indicated for:

• Maintenance treatment of severe asthma in adults and adolescents

• Long-term management of COPD with frequent exacerbations

• Prevention of bronchospasm and asthma attacks in patients requiring high-dose ICS therapy

• Patients inadequately controlled on lower doses of Salmeterol/Fluticasone combination

• Improvement of lung function, symptom control, and quality of life

Mechanism of Action

The combination works through two complementary mechanisms:

1. Salmeterol (Long-acting beta-2 agonist):

   • Stimulates beta-2 adrenergic receptors in the bronchial smooth muscles

   • Induces long-lasting bronchodilation, improving airflow and reducing wheezing, breathlessness, and chest tightness

   • Duration of action is approximately 12 hours, supporting twice-daily dosing

2. Fluticasone Propionate (Inhaled corticosteroid):

   • Reduces airway inflammation, edema, and mucus production by inhibiting inflammatory cells and mediators

   • Prevents airway remodeling and reduces the frequency of exacerbations

   • Supports long-term control of chronic respiratory conditions

The combination ensures optimal airway patency and anti-inflammatory protection, improving overall respiratory function.

Dosage and Administration

• Adults and adolescents: 1 capsule inhaled twice daily using a dry powder inhaler

• Use at the same time each day to maintain consistent therapeutic effect

• Not suitable as a rescue inhaler; a short-acting bronchodilator should be used for sudden attacks

• Rinse mouth thoroughly after each inhalation to reduce the risk of oral thrush and irritation

• Regular monitoring of lung function, symptoms, and inhaler technique is essential

Precautions and Warnings

• Not intended for acute bronchospasm or asthma attacks

• Use caution in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders

• Avoid abrupt discontinuation to prevent adrenal insufficiency

• Report any paradoxical bronchospasm, worsening symptoms, or allergic reactions immediately

• Pediatric, elderly, or pregnant patients should use under strict medical supervision

Possible Side Effects

Salflu Inhalation Capsule 50 mcg+500 mcg is generally well tolerated. Common side effects include:

• Throat irritation or hoarseness

• Oral candidiasis (thrush)

• Headache or mild dizziness

• Tremors or palpitations (rare, due to Salmeterol)

• Rare systemic corticosteroid effects, such as adrenal suppression

Most side effects are mild and can be minimized with proper inhalation technique and mouth rinsing.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Storage Instructions

• Store in a cool, dry place below 30°C

• Protect from light and moisture

• Keep out of reach of children

• Do not swallow or puncture capsules

Conclusion

Salflu Inhalation Capsule 50 mcg+500 mcg (Salmeterol + Fluticasone Propionate) is a high-potency inhalation therapy for severe asthma and COPD. Its dual mechanism of bronchodilation and anti-inflammatory action provides improved lung function, reduces exacerbations, and enhances patient quality of life. Consistent use under physician guidance, along with proper inhaler technique, ensures optimal respiratory control and long-term disease management.