Soforal Tablet 400 mg contains Sofosbuvir, a direct-acting antiviral (DAA) medication used in the treatment of chronic Hepatitis C virus (HCV) infection. It is an essential component of modern HCV therapy and is typically used in combination with other antiviral agents to achieve sustained virologic response (SVR), effectively curing the infection in most patients.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Sofosbuvir 400 mg

Mechanism of Action

Sofosbuvir is a nucleotide analog inhibitor that targets the HCV NS5B RNA-dependent RNA polymerase enzyme. By inhibiting this enzyme, it prevents viral replication and reduces the amount of Hepatitis C virus in the body. This leads to gradual elimination of the virus when used in combination therapy.

Indications

Soforal Tablet 400 mg is indicated for:

• Treatment of chronic Hepatitis C virus (HCV) infection
• Use in combination with other antiviral agents such as ledipasvir, velpatasvir, or ribavirin depending on genotype and clinical condition
• Patients with or without compensated liver disease

Dosage and Administration

• The usual dose is 400 mg once daily, taken orally.
• Must be used in combination with other antiviral medications as prescribed.
• Can be taken with or without food.
• Treatment duration depends on HCV genotype, liver condition, and physician recommendation.
• Strict adherence to the prescribed regimen is essential for successful treatment outcomes.

Benefits

• Highly effective in treating chronic Hepatitis C infection
• Shortens treatment duration compared to older therapies
• High sustained virologic response (SVR) rates
• Oral once-daily dosing improves patient compliance
• Well-tolerated in most patients

Side Effects

Common side effects may include:

• Fatigue
• Headache
• Nausea
• Insomnia
• Mild anemia (especially in combination therapy)

Rare but serious side effects may include severe bradycardia (when used with certain heart medications), allergic reactions, or worsening liver function in advanced disease.

Precautions and Warnings

• Should always be used in combination therapy as prescribed.
• Not recommended as monotherapy for Hepatitis C.
• Use with caution in patients with severe liver disease.
• Regular monitoring of liver function is required during treatment.
• Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.
• Caution in patients with a history of heart disease when used with certain antivirals.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Soforal Tablet may interact with:

• Amiodarone (risk of severe bradycardia)
• Anticonvulsants (may reduce effectiveness)
• Rifampin and other enzyme inducers
• Certain antiretroviral drugs

Always inform your healthcare provider about all medications being taken.

Storage

• Store below 30°C in a dry place
• Protect from light and moisture
• Keep out of reach of children.