Sotoras Tablet 120 mg contains Sotorasib, an oral targeted cancer therapy used in the treatment of certain types of non-small cell lung cancer (NSCLC) with specific genetic mutations. It is a KRAS G12C inhibitor that works by targeting and blocking a key abnormal protein responsible for cancer cell growth. This precision medicine helps slow disease progression in eligible patients under oncologist supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Composition

• Active Ingredient: Sotorasib 120 mg

Mechanism of Action

Sotorasib is a targeted inhibitor of the KRAS G12C mutation. The KRAS protein plays a critical role in cell signaling pathways that control cell growth and division. In cancer, the mutated KRAS G12C protein remains permanently active, leading to uncontrolled tumor growth. Sotorasib binds irreversibly to this mutated protein and locks it in an inactive state, thereby inhibiting cancer cell proliferation and tumor progression.

Indications

Sotoras Tablet 120 mg is indicated for:

• Treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) with KRAS G12C mutation
• Patients who have received at least one prior systemic therapy
• Use as determined by genetic testing and oncologist recommendation

Dosage and Administration

• The usual dose is determined by an oncologist based on clinical condition.
• Taken orally once daily, with or without food.
• Tablets should be swallowed whole with water; do not crush or chew.
• Treatment should be continued as long as clinical benefit is observed or as directed by the physician.

Benefits

• Targets specific genetic mutation (KRAS G12C) in cancer cells
• Helps slow tumor growth and disease progression
• Oral therapy allows convenient outpatient treatment
• Provides a personalized approach to cancer management
• May improve progression-free survival in eligible patients

Side Effects

Common side effects may include:

• Diarrhea
• Nausea or vomiting
• Fatigue
• Liver enzyme elevation
• Decreased appetite
• Muscle or joint pain

Serious side effects may include liver toxicity, severe diarrhea, or lung inflammation (pneumonitis). Immediate medical attention is required if severe symptoms occur.

Precautions and Warnings

• Must be used only under the supervision of an oncologist.
• Regular monitoring of liver function tests is required during treatment.
• Not recommended during pregnancy due to potential fetal harm.
• Effective contraception should be used during treatment and for a period after stopping therapy.
• Use caution in patients with pre-existing liver disease.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Sotoras Tablet may interact with:

• Acid-reducing agents (PPIs, H2 blockers)
• CYP3A4 inducers or inhibitors
• Certain chemotherapy or targeted cancer therapies
• Herbal supplements such as St. John’s Wort

Always inform your healthcare provider about all medications being taken.

Storage

• Store below 30°C in a cool, dry place
• Protect from moisture and light
• Keep out of reach of children.