Toco Injection 37.5 mg/5 ml contains Atosiban Acetate, a selective oxytocin receptor antagonist used in obstetric practice to manage threatened preterm labor. It works by reducing uterine contractions, helping to temporarily delay premature birth and allow time for further fetal development under medical supervision.

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Indications

Toco Injection is indicated for:

• Threatened preterm labor in pregnant women with regular uterine contractions
• Short-term postponement of preterm delivery
• Cases requiring delay of labor to allow administration of corticosteroids for fetal lung maturation

Mechanism of Action

Atosiban selectively blocks oxytocin receptors in the uterus and reduces prostaglandin release. This results in:

• Inhibition of uterine smooth muscle contractions
• Relaxation of the uterus
• Delay in the progression of preterm labor

Dosage and Administration

• Administered intravenously under strict hospital supervision only
• Initial bolus dose is typically followed by a continuous infusion as per clinical protocol
• Total treatment duration is generally up to 48 hours
• Dosage must be determined and administered by a qualified healthcare professional

Benefits

• Helps delay preterm labor effectively
• Provides time for fetal lung maturation therapy
• Reduces complications associated with premature delivery
• Generally well tolerated in clinical use

Side Effects

Common side effects may include:

• Nausea
• Headache
• Dizziness
• Flushing
• Injection site reactions

Less common but serious side effects:

• Uterine bleeding
• Hypotension
• Fetal heart rate changes
• Allergic reactions

Continuous maternal and fetal monitoring is required during administration.

Precautions and Warnings

• For hospital use only under specialist supervision
• Not suitable for long-term tocolysis
• Contraindicated in cases such as intrauterine fetal death or severe maternal conditions where continuation of pregnancy is unsafe
• Careful monitoring of fetal and maternal status is essential
• Use with caution in patients with cardiovascular disorders

রেজিস্টার্ড চিকিৎসকের পরামর্শ অনুযায়ী ঔষধ সেবন করুন

Drug Interactions

Toco Injection may interact with:

• Other tocolytic agents
• Oxytocin (antagonistic effect)
• Antihypertensive medications

It should only be used under strict clinical supervision.

Storage

• Store below 25°C in a cool, dry place
• Protect from light
• Do not freeze
• Keep out of reach of children.